(3R,4S)-4-Benzyloxy-5-(tert-butyl-diphenyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxymethyl)-pent-1-yn-3-ol

Base Information

Chemical Name:(3R,4S)-4-Benzyloxy-5-(tert-butyl-diphenyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxymethyl)-pent-1-yn-3-ol
CAS No.:201553-27-7
Molecular Formula:C₄₅H₅₂O₄Si₂
Molecular Weight:713.076
Hs Code.:

Synonyms:(3R,4S)-4-Benzyloxy-5-(tert-butyl-diphenyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxymethyl)-pent-1-yn-3-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,4S)-4-Benzyloxy-5-(tert-butyl-diphenyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxymethyl)-pent-1-yn-3-ol

Chemical Property:

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Technology Process of (3R,4S)-4-Benzyloxy-5-(tert-butyl-diphenyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxymethyl)-pent-1-yn-3-ol

There total 1 articles about (3R,4S)-4-Benzyloxy-5-(tert-butyl-diphenyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxymethyl)-pent-1-yn-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 183888-69-9
(3R)-3-benzyloxy-1,4-bis(tert-butyl-diphenyl-silyloxy)butan-2-one

: 4301-14-8
acetylenemagnesium bromide

: 201553-27-7
(3R,4S)-4-Benzyloxy-5-(tert-butyl-diphenyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxymethyl)-pent-1-yn-3-ol

: (3S,4S)-4-Benzyloxy-5-(tert-butyl-diphenyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxymethyl)-pent-1-yn-3-ol

Guidance literature:: In tetrahydrofuran; at 0 ℃; for 1h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
DOI:10.1021/jo9716744

Reference yield:

: 201553-27-7
(3R,4S)-4-Benzyloxy-5-(tert-butyl-diphenyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxymethyl)-pent-1-yn-3-ol

: 201553-25-5
(2S,3R)-2-Benzyloxy-1-(tert-butyl-diphenyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxymethyl)-pentan-3-ol

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; for 3h; Ambient temperature;
DOI:10.1021/jo9716744

Reference yield:

: 201553-27-7
(3R,4S)-4-Benzyloxy-5-(tert-butyl-diphenyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxymethyl)-pent-1-yn-3-ol

: (2R,3S)-1,3,4-tri-O-benzyl-2-ethylbutane-1,2,3,4-tetraol

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Pd/C / ethyl acetate / 3 h / Ambient temperature

2: Bu₄NF*3H₂O / tetrahydrofuran / 0.5 h / Ambient temperature

3: NaH, Bu₄NI / tetrahydrofuran / 1.5 h / Heating

With tetrabutyl ammonium fluoride; hydrogen; tetra-(n-butyl)ammonium iodide; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate;
DOI:10.1021/jo9716744