α,α'-bis<(2S,5S)-2-t-butyl-1-t-butyloxycarbonyl-3-methyl-4-imidazolidinon-5-yl>-o-xylol

Base Information

Chemical Name:α,α'-bis<(2S,5S)-2-t-butyl-1-t-butyloxycarbonyl-3-methyl-4-imidazolidinon-5-yl>-o-xylol
CAS No.:119838-27-6
Molecular Formula:C₃₄H₅₄N₄O₆
Molecular Weight:614.826
Hs Code.:

Synonyms:α,α'-bis<(2S,5S)-2-t-butyl-1-t-butyloxycarbonyl-3-methyl-4-imidazolidinon-5-yl>-o-xylol

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Chemical Property of α,α'-bis<(2S,5S)-2-t-butyl-1-t-butyloxycarbonyl-3-methyl-4-imidazolidinon-5-yl>-o-xylol

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Technology Process of α,α'-bis<(2S,5S)-2-t-butyl-1-t-butyloxycarbonyl-3-methyl-4-imidazolidinon-5-yl>-o-xylol

There total 3 articles about α,α'-bis<(2S,5S)-2-t-butyl-1-t-butyloxycarbonyl-3-methyl-4-imidazolidinon-5-yl>-o-xylol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 119838-38-9
(2S)-1-(tert-butyloxycarbonyl)-2-tert-butyl-3-methylimidazolidin-4-one

: 91-13-4
α,α'-dibromo-o-xylene

: 119838-27-6
α,α'-bis<(2S,5S)-2-t-butyl-1-t-butyloxycarbonyl-3-methyl-4-imidazolidinon-5-yl>-o-xylol

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -80 - -40 ℃;
DOI:10.1016/S0040-4020(01)86036-1

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 119838-27-6
α,α'-bis<(2S,5S)-2-t-butyl-1-t-butyloxycarbonyl-3-methyl-4-imidazolidinon-5-yl>-o-xylol

Guidance literature:: Multi-step reaction with 2 steps

1: 74 percent / 1.) 2N NaOH; 2.) p-dimethylaminopyridine, triethylamine / Ambient temperature; 1.) CH₂Cl₂, 2.) acetone, RT, 8 h

2: 78 percent / LDA / tetrahydrofuran; hexane / -80 - -40 °C

With dmap; sodium hydroxide; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; hexane;
DOI:10.1016/S0040-4020(01)86036-1

Reference yield:

: 119838-38-9
(2S)-1-(tert-butyloxycarbonyl)-2-tert-butyl-3-methylimidazolidin-4-one

: 91-13-4
α,α'-dibromo-o-xylene

: 119838-27-6
α,α'-bis<(2S,5S)-2-t-butyl-1-t-butyloxycarbonyl-3-methyl-4-imidazolidinon-5-yl>-o-xylol

: 123053-19-0
(2S,5S)-5-(2-Bromomethyl-benzyl)-2-tert-butyl-3-methyl-4-oxo-imidazolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With lithium diisopropyl amide; lithium bromide; Yield given. Multistep reaction. Yields of byproduct given; 1.) THF, hexane, -78 deg C, 40 min: 2.) THF, hexane, -78 deg C, 2 h;