N-(N-(Boc)-allylglycyl)-N-(2,4-dimethoxybenzyl)homoallylglycine methyl ester

Base Information

Chemical Name:N-(N-(Boc)-allylglycyl)-N-(2,4-dimethoxybenzyl)homoallylglycine methyl ester
CAS No.:851909-00-7
Molecular Formula:C₂₆H₃₈N₂O₇
Molecular Weight:490.597
Hs Code.:

Synonyms:N-(N-(Boc)-allylglycyl)-N-(2,4-dimethoxybenzyl)homoallylglycine methyl ester

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Chemical Property of N-(N-(Boc)-allylglycyl)-N-(2,4-dimethoxybenzyl)homoallylglycine methyl ester

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Technology Process of N-(N-(Boc)-allylglycyl)-N-(2,4-dimethoxybenzyl)homoallylglycine methyl ester

There total 10 articles about N-(N-(Boc)-allylglycyl)-N-(2,4-dimethoxybenzyl)homoallylglycine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 851909-11-0
methyl (2S)-2-[(2,4-dimethoxybenzyl)amino]hex-5-enoate

: 90600-20-7
(2S)-2-[(tert-butoxycarbonyl)amino]pent-4-enoic acid

: 851909-00-7
N-(N-(Boc)-allylglycyl)-N-(2,4-dimethoxybenzyl)homoallylglycine methyl ester

Guidance literature:: With N-ethylmorpholine;; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1021/jo0477648

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 851909-00-7
N-(N-(Boc)-allylglycyl)-N-(2,4-dimethoxybenzyl)homoallylglycine methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / NaOH / H₂O; dioxane / 18 h

2: 86 percent / N-ethylmorpholine; HATU / CH₂Cl₂ / 24 h / 20 °C

With N-ethylmorpholine;; sodium hydroxide; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1,4-dioxane; dichloromethane; water;
DOI:10.1021/jo0477648

Reference yield:

: 613-45-6
2,4-Dimethoxybenzaldehyde

: 851909-00-7
N-(N-(Boc)-allylglycyl)-N-(2,4-dimethoxybenzyl)homoallylglycine methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / NaBH(OAc)3 / CH₂Cl₂ / 18 h / 20 °C

2: 86 percent / N-ethylmorpholine; HATU / CH₂Cl₂ / 24 h / 20 °C

With N-ethylmorpholine;; sodium tris(acetoxy)borohydride; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane;
DOI:10.1021/jo0477648