N-[5-({2-[(cyclopropylcarbonyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)-2-methylphenyl]-2-methylpropanecarboxamide

Base Information

Chemical Name:N-[5-({2-[(cyclopropylcarbonyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)-2-methylphenyl]-2-methylpropanecarboxamide
CAS No.:1092391-91-7
Molecular Formula:C₂₂H₂₅N₅O₃
Molecular Weight:407.472
Hs Code.:

Synonyms:N-[5-({2-[(cyclopropylcarbonyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)-2-methylphenyl]-2-methylpropanecarboxamide

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Chemical Property of N-[5-({2-[(cyclopropylcarbonyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)-2-methylphenyl]-2-methylpropanecarboxamide

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Technology Process of N-[5-({2-[(cyclopropylcarbonyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)-2-methylphenyl]-2-methylpropanecarboxamide

There total 9 articles about N-[5-({2-[(cyclopropylcarbonyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)-2-methylphenyl]-2-methylpropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1092394-73-4
N-[6-(3-amino-4-methylphenoxy)[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide

: 108-12-3
isopentanoyl chloride

: 1092391-91-7
N-[5-({2-[(cyclopropylcarbonyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)-2-methylphenyl]-2-methylpropanecarboxamide

Guidance literature:: N-[6-(3-amino-4-methylphenoxy)[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide; isopentanoyl chloride; In N,N-dimethyl acetamide; at 20 ℃; for 12h;

With water; sodium hydrogencarbonate; In N,N-dimethyl acetamide;

Reference yield:

: 1092394-22-3
tert-butyl {2-methyl-5-[(6-nitropyridin-3-yl)oxy]phenyl}carbamate

: 1092391-91-7
N-[5-({2-[(cyclopropylcarbonyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)-2-methylphenyl]-2-methylpropanecarboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: palladium on activated charcoal; hydrogen / methanol / 12 h / 20 °C

2: dimethyl sulfoxide / 15 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; hydroxylamine hydrochloride / ethanol; methanol

4: N,N-dimethyl acetamide / 2 h / 20 °C

5: trifluoroacetic acid / 0.5 h / 0 °C

6: N,N-dimethyl acetamide / 2 h / 0 - 20 °C

With palladium on activated charcoal; hydroxylamine hydrochloride; hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In methanol; ethanol; N,N-dimethyl acetamide; dimethyl sulfoxide;
DOI:10.1016/j.bmc.2013.04.042

Reference yield:

: 1092394-71-2
tert-butyl {5-[(2-amino[1,2,4]triazolo[1,5-a]pyridin-6-yl)oxy]-2-methylphenyl}carbamate

: 1092391-91-7
N-[5-({2-[(cyclopropylcarbonyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)-2-methylphenyl]-2-methylpropanecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethyl acetamide / 2 h / 20 °C

2: trifluoroacetic acid / 0.5 h / 0 °C

3: N,N-dimethyl acetamide / 2 h / 0 - 20 °C

With trifluoroacetic acid; In N,N-dimethyl acetamide;
DOI:10.1016/j.bmc.2013.04.042