(Z)-(S)-6-(tert-Butyl-diphenyl-silanyloxy)-4-chloro-1-(4-methoxy-benzyloxy)-hex-3-en-2-ol

Base Information

Chemical Name:(Z)-(S)-6-(tert-Butyl-diphenyl-silanyloxy)-4-chloro-1-(4-methoxy-benzyloxy)-hex-3-en-2-ol
CAS No.:203307-28-2
Molecular Formula:C₃₀H₃₇ClO₄Si
Molecular Weight:525.16
Hs Code.:

Synonyms:(Z)-(S)-6-(tert-Butyl-diphenyl-silanyloxy)-4-chloro-1-(4-methoxy-benzyloxy)-hex-3-en-2-ol

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Chemical Property of (Z)-(S)-6-(tert-Butyl-diphenyl-silanyloxy)-4-chloro-1-(4-methoxy-benzyloxy)-hex-3-en-2-ol

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Technology Process of (Z)-(S)-6-(tert-Butyl-diphenyl-silanyloxy)-4-chloro-1-(4-methoxy-benzyloxy)-hex-3-en-2-ol

There total 7 articles about (Z)-(S)-6-(tert-Butyl-diphenyl-silanyloxy)-4-chloro-1-(4-methoxy-benzyloxy)-hex-3-en-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (S)-1-((4-methoxybenzyl)oxy)but-3-yn-2-ol

: 203307-28-2
(Z)-(S)-6-(tert-Butyl-diphenyl-silanyloxy)-4-chloro-1-(4-methoxy-benzyloxy)-hex-3-en-2-ol

Guidance literature:: Multi-step reaction with 7 steps

1: PPTS / CH₂Cl₂

2: 94 percent / n-BuLi, BF₃*Et₂O / tetrahydrofuran / 0.5 h / -78 °C

3: 74 percent / n-Bu₄NF / tetrahydrofuran / Ambient temperature

4: 1.) NaIO₄; 2.) NaBH₄ / 1.) 1,4-dioxane, H₂O; 2.) 1,4-dioxane, H₂O

5: 90 percent / imidazole / dimethylformamide

6: 87 percent / PPTS / methanol / 50 °C

7: 1.) Red-Al; 2.) N-chlorosuccinimide / 1.) THF, -78 deg C to 0 deg C, 1 h; 2.) THF, 0 deg C, 30 min

With 1H-imidazole; sodium tetrahydroborate; sodium periodate; N-chloro-succinimide; n-butyllithium; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(97)10714-6

Reference yield:

: 203307-23-7
2-[(S)-1-(4-Methoxy-benzyloxymethyl)-prop-2-ynyloxy]-tetrahydro-pyran

: 203307-28-2
(Z)-(S)-6-(tert-Butyl-diphenyl-silanyloxy)-4-chloro-1-(4-methoxy-benzyloxy)-hex-3-en-2-ol

Guidance literature:: Multi-step reaction with 6 steps

1: 94 percent / n-BuLi, BF₃*Et₂O / tetrahydrofuran / 0.5 h / -78 °C

2: 74 percent / n-Bu₄NF / tetrahydrofuran / Ambient temperature

3: 1.) NaIO₄; 2.) NaBH₄ / 1.) 1,4-dioxane, H₂O; 2.) 1,4-dioxane, H₂O

4: 90 percent / imidazole / dimethylformamide

5: 87 percent / PPTS / methanol / 50 °C

6: 1.) Red-Al; 2.) N-chlorosuccinimide / 1.) THF, -78 deg C to 0 deg C, 1 h; 2.) THF, 0 deg C, 30 min

With 1H-imidazole; sodium tetrahydroborate; sodium periodate; N-chloro-succinimide; n-butyllithium; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(97)10714-6

Reference yield:

: 203307-25-9
(S)-6-(4-Methoxy-benzyloxy)-5-(tetrahydro-pyran-2-yloxy)-hex-3-yn-1-ol

: 203307-28-2
(Z)-(S)-6-(tert-Butyl-diphenyl-silanyloxy)-4-chloro-1-(4-methoxy-benzyloxy)-hex-3-en-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / imidazole / dimethylformamide

2: 87 percent / PPTS / methanol / 50 °C

3: 1.) Red-Al; 2.) N-chlorosuccinimide / 1.) THF, -78 deg C to 0 deg C, 1 h; 2.) THF, 0 deg C, 30 min

With 1H-imidazole; N-chloro-succinimide; pyridinium p-toluenesulfonate; sodium bis(2-methoxyethoxy)aluminium dihydride; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(97)10714-6