(E)-N'-((2-(4-fluorophenoxy)quinolin-3-yl)methylene)-2-(2-methyl-5-nitro-1H-imidazol-1-yl)acetohydrazide

Base Information

Chemical Name:(E)-N'-((2-(4-fluorophenoxy)quinolin-3-yl)methylene)-2-(2-methyl-5-nitro-1H-imidazol-1-yl)acetohydrazide
CAS No.:1594986-90-9
Molecular Formula:C₂₂H₁₇FN₆O₄
Molecular Weight:448.413
Hs Code.:

Synonyms:(E)-N'-((2-(4-fluorophenoxy)quinolin-3-yl)methylene)-2-(2-methyl-5-nitro-1H-imidazol-1-yl)acetohydrazide

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Chemical Property of (E)-N'-((2-(4-fluorophenoxy)quinolin-3-yl)methylene)-2-(2-methyl-5-nitro-1H-imidazol-1-yl)acetohydrazide

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Technology Process of (E)-N'-((2-(4-fluorophenoxy)quinolin-3-yl)methylene)-2-(2-methyl-5-nitro-1H-imidazol-1-yl)acetohydrazide

There total 3 articles about (E)-N'-((2-(4-fluorophenoxy)quinolin-3-yl)methylene)-2-(2-methyl-5-nitro-1H-imidazol-1-yl)acetohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 126359-46-4
2-(2-methyl-5-nitro-1H-imidazol-1-yl)acetohydrazide

: 1039878-84-6
C₁₆H₁₀FNO₂

: 1594986-90-9
(E)-N'-((2-(4-fluorophenoxy)quinolin-3-yl)methylene)-2-(2-methyl-5-nitro-1H-imidazol-1-yl)acetohydrazide

Guidance literature:: With nickel(II) nitrate hexahydrate; In ethanol; Reflux;
DOI:10.1016/j.bmcl.2014.02.041

Reference yield:

: 1016-40-6
ethyl 2-(2-methyl-5-nitro-1H-imidazole-1-yl)acetate

: 1594986-90-9
(E)-N'-((2-(4-fluorophenoxy)quinolin-3-yl)methylene)-2-(2-methyl-5-nitro-1H-imidazol-1-yl)acetohydrazide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine / methanol; water

2: nickel(II) nitrate hexahydrate / ethanol / Reflux

With nickel(II) nitrate hexahydrate; hydrazine; In methanol; ethanol; water;
DOI:10.1016/j.bmcl.2014.02.041

Reference yield:

: 371-41-5
4-Fluorophenol

: 73568-25-9
2-chloro-3-quinoline carboxaldehyde

: 1594986-90-9
(E)-N'-((2-(4-fluorophenoxy)quinolin-3-yl)methylene)-2-(2-methyl-5-nitro-1H-imidazol-1-yl)acetohydrazide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 3.5 h / Reflux

2: nickel(II) nitrate hexahydrate / ethanol / Reflux

With nickel(II) nitrate hexahydrate; potassium carbonate; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2014.02.041