ethyl (2E)-3-{5-[2-methoxy-3-(trifluoromethyl)phenyl]furan-2-yl}prop-2-enoate

Base Information

Chemical Name:ethyl (2E)-3-{5-[2-methoxy-3-(trifluoromethyl)phenyl]furan-2-yl}prop-2-enoate
CAS No.:1198181-55-3
Molecular Formula:C₁₇H₁₅F₃O₄
Molecular Weight:340.299
Hs Code.:

Synonyms:ethyl (2E)-3-{5-[2-methoxy-3-(trifluoromethyl)phenyl]furan-2-yl}prop-2-enoate

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Chemical Property of ethyl (2E)-3-{5-[2-methoxy-3-(trifluoromethyl)phenyl]furan-2-yl}prop-2-enoate

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Technology Process of ethyl (2E)-3-{5-[2-methoxy-3-(trifluoromethyl)phenyl]furan-2-yl}prop-2-enoate

There total 3 articles about ethyl (2E)-3-{5-[2-methoxy-3-(trifluoromethyl)phenyl]furan-2-yl}prop-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 395-48-2
1-methoxy-2-(trifluoromethyl)benzene

: 50527-72-5
3-(5-bromo-furan-2-yl)-acrylic acid ethyl ester

: 1198181-56-4
ethyl (2E)-3-{5-[3-methoxy-2-(trifluoromethyl)phenyl]furan-2-yl}prop-2-enoate

: 1198181-55-3
ethyl (2E)-3-{5-[2-methoxy-3-(trifluoromethyl)phenyl]furan-2-yl}prop-2-enoate

Guidance literature:: 1-methoxy-2-(trifluoromethyl)benzene; With n-butyllithium; In tetrahydrofuran; hexane; at 20 ℃; for 1h;

With Triisopropyl borate; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 16.5h;

3-(5-bromo-furan-2-yl)-acrylic acid ethyl ester;

Reference yield: 53.0%

: 1072946-62-3
2-methoxy-3-trifluoromethyl-phenylboronic acid

: 1198181-64-4
[3-methoxy-2-(trifluoromethyl)phenyl]boronic acid

: 50527-72-5
3-(5-bromo-furan-2-yl)-acrylic acid ethyl ester

: 1198181-56-4
ethyl (2E)-3-{5-[3-methoxy-2-(trifluoromethyl)phenyl]furan-2-yl}prop-2-enoate

: 1198181-55-3
ethyl (2E)-3-{5-[2-methoxy-3-(trifluoromethyl)phenyl]furan-2-yl}prop-2-enoate

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; for 16h; Inert atmosphere;

Reference yield:

: 1899-24-7
5-bromo-2-furancarboxaldehyde

: 1198181-55-3
ethyl (2E)-3-{5-[2-methoxy-3-(trifluoromethyl)phenyl]furan-2-yl}prop-2-enoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; oil / 0.25 h / 20 °C / Inert atmosphere

1.2: 1 h / 20 °C / Inert atmosphere

2.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / 20 °C

2.2: 16.5 h / -78 - 20 °C

With n-butyllithium; sodium hydride; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; oil;