(2R)-3-[(10R,11S)-11-azido-2-fluoro-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-10-yl]-2-hydroxypropyl 4-methylbenzenesulfonate

Base Information

Chemical Name:(2R)-3-[(10R,11S)-11-azido-2-fluoro-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-10-yl]-2-hydroxypropyl 4-methylbenzenesulfonate
CAS No.:890749-93-6
Molecular Formula:C₂₅H₂₄FN₃O₄S
Molecular Weight:481.548
Hs Code.:

Synonyms:(2R)-3-[(10R,11S)-11-azido-2-fluoro-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-10-yl]-2-hydroxypropyl 4-methylbenzenesulfonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R)-3-[(10R,11S)-11-azido-2-fluoro-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-10-yl]-2-hydroxypropyl 4-methylbenzenesulfonate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (2R)-3-[(10R,11S)-11-azido-2-fluoro-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-10-yl]-2-hydroxypropyl 4-methylbenzenesulfonate

There total 5 articles about (2R)-3-[(10R,11S)-11-azido-2-fluoro-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-10-yl]-2-hydroxypropyl 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 890749-86-7
(2R)-3-[(10R,11S)-11-azido-2-fluoro-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-10-yl]-1,2-propanediol

: 98-59-9
p-toluenesulfonyl chloride

: 890749-93-6
(2R)-3-[(10R,11S)-11-azido-2-fluoro-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-10-yl]-2-hydroxypropyl 4-methylbenzenesulfonate

Guidance literature:: With di(n-butyl)tin oxide; triethylamine; In toluene; at 20 ℃;

Reference yield:

: 543741-46-4
(11R)-11-{[(4R)-2,2-dimethyl-1,3-dioxolane-4-yl]methyl}-8-fluoro-5,11-dihydro-10H-dibenzo[a,d]cyclohepten-10-one

: 890749-93-6
(2R)-3-[(10R,11S)-11-azido-2-fluoro-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-10-yl]-2-hydroxypropyl 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium tetrahydroborate / isopropyl alcohol / 1 h / 0 - 20 °C / pH 7 / Aqueous phosphate buffer

2.1: di-isopropyl azodicarboxylate / tetrahydrofuran / 0.33 h / -30 °C

2.2: -30 - 20 °C

3.1: hydrogenchloride / tetrahydrofuran; water / 8 h / 20 °C

3.2: 0 °C

4.1: triethylamine / di(n-butyl)tin oxide / toluene / 20 °C

With hydrogenchloride; sodium tetrahydroborate; di-isopropyl azodicarboxylate; triethylamine; di(n-butyl)tin oxide; In tetrahydrofuran; water; isopropyl alcohol; toluene;

Reference yield:

: 887611-88-3
(11Z)-11-{[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methylene}-8-fluoro-5,11-dihydro-10H-dibenzo[a,d]cyclohepten-10-one

: 890749-93-6
(2R)-3-[(10R,11S)-11-azido-2-fluoro-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-10-yl]-2-hydroxypropyl 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen; triethylamine / palladium 10% on activated carbon / isopropyl alcohol / 6 h

1.2: 1 h / 40 °C

2.1: sodium tetrahydroborate / isopropyl alcohol / 1 h / 0 - 20 °C / pH 7 / Aqueous phosphate buffer

3.1: di-isopropyl azodicarboxylate / tetrahydrofuran / 0.33 h / -30 °C

3.2: -30 - 20 °C

4.1: hydrogenchloride / tetrahydrofuran; water / 8 h / 20 °C

4.2: 0 °C

5.1: triethylamine / di(n-butyl)tin oxide / toluene / 20 °C

With hydrogenchloride; sodium tetrahydroborate; di-isopropyl azodicarboxylate; hydrogen; triethylamine; palladium 10% on activated carbon; di(n-butyl)tin oxide; In tetrahydrofuran; water; isopropyl alcohol; toluene;