2-(2-fluoro-4-biphenyl) p-toluenesulfonylpropionate

Base Information

Chemical Name:2-(2-fluoro-4-biphenyl) p-toluenesulfonylpropionate
CAS No.:346435-74-3
Molecular Formula:C₂₂H₂₁FO₃S
Molecular Weight:384.471
Hs Code.:

Synonyms:2-(2-fluoro-4-biphenyl) p-toluenesulfonylpropionate

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Chemical Property of 2-(2-fluoro-4-biphenyl) p-toluenesulfonylpropionate

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Technology Process of 2-(2-fluoro-4-biphenyl) p-toluenesulfonylpropionate

There total 3 articles about 2-(2-fluoro-4-biphenyl) p-toluenesulfonylpropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 64858-91-9
2-(2-fluoro-biphenyl-4-yl)-propan-1-ol

: 98-59-9
p-toluenesulfonyl chloride

: 346435-74-3
2-(2-fluoro-4-biphenyl) p-toluenesulfonylpropionate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 5104-49-4
fluorobiprofen

: 346435-74-3
2-(2-fluoro-4-biphenyl) p-toluenesulfonylpropionate

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / SOCl₂ / 6 h / Heating

2: 78 percent / LAH / diethyl ether / 8 h / Heating

3: 92 percent / Et₃N / CH₂Cl₂ / 0 - 20 °C

With lithium aluminium tetrahydride; thionyl chloride; triethylamine; In diethyl ether; dichloromethane;

Reference yield:

: 64858-90-8
ethyl 2-(2-fluoro-4-biphenylyl)-propionate

: 346435-74-3
2-(2-fluoro-4-biphenyl) p-toluenesulfonylpropionate

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / LAH / diethyl ether / 8 h / Heating

2: 92 percent / Et₃N / CH₂Cl₂ / 0 - 20 °C

With lithium aluminium tetrahydride; triethylamine; In diethyl ether; dichloromethane;