N-(3,4-difluoro-benzyl)-2-piperidin-4-ylidene-acetamide hydrochloride

Base Information

• Chemical Name: N-(3,4-difluoro-benzyl)-2-piperidin-4-ylidene-acetamide hydrochloride
• CAS No.: 1045708-81-3
• Molecular Formula: C₁₄H₁₆F₂N₂O*ClH
• Molecular Weight: 302.752

Synonyms:N-(3,4-difluoro-benzyl)-2-piperidin-4-ylidene-acetamide hydrochloride

Chemical Property of N-(3,4-difluoro-benzyl)-2-piperidin-4-ylidene-acetamide hydrochloride

Chemical Property:

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Technology Process of N-(3,4-difluoro-benzyl)-2-piperidin-4-ylidene-acetamide hydrochloride

There total 1 articles about N-(3,4-difluoro-benzyl)-2-piperidin-4-ylidene-acetamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-[(3,4-difluoro-benzylcarbamoyl)-methylene]-piperidine-1-carboxylic acid tert-butyl ester (1045708-80-2) → N-(3,4-difluoro-benzyl)-2-piperidin-4-ylidene-acetamide hydrochloride (1045708-81-3)

Guidance literature:

With hydrogenchloride; In diethyl ether; dichloromethane; at 20 ℃; for 18h;

Reference yield:

N-(3,4-difluoro-benzyl)-2-piperidin-4-ylidene-acetamide hydrochloride (1045708-81-3) + (2-bromoethyl)-4-fluorobenzene (332-42-3) → N-(3,4-difluoro-benzyl)-2-{1-[2-(4-fluoro-phenyl)-ethyl]-piperidin-4-ylidene}-acetamide (1045708-76-6)

Guidance literature:

With triethylamine; potassium iodide; In dichloromethane; for 4h; Heating / reflux;

Reference yield:

N-(3,4-difluoro-benzyl)-2-piperidin-4-ylidene-acetamide hydrochloride (1045708-81-3) + 4-fluorobenzaldehyde (459-57-4) → N-(3,4-difluoro-benzyl)-2-[1-(4-fluoro-benzyl)-piperidin-4-ylidene]-acetamide (1045708-60-8)

Guidance literature:

With sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; at 20 ℃; for 18h;

upstream raw materials:

4-[(3,4-difluoro-benzylcarbamoyl)-methylene]-piperidine-1-carboxylic acid tert-butyl ester

Downstream raw materials:

N-(3,4-difluoro-benzyl)-2-{1-[2-(4-fluoro-phenyl)-ethyl]-piperidin-4-ylidene}-acetamide

N-(3,4-difluoro-benzyl)-2-[1-(4-fluoro-benzyl)-piperidin-4-ylidene]-acetamide

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