Lithium (R)-4-benzyloxy-2-(4-benzyloxycarbonyl-7-oxo-[1,4]diazepan-1-yl)-butyrate

Base Information

Chemical Name:Lithium (R)-4-benzyloxy-2-(4-benzyloxycarbonyl-7-oxo-[1,4]diazepan-1-yl)-butyrate
CAS No.:1290049-11-4
Molecular Formula:C₂₄H₂₇N₂O₆*Li
Molecular Weight:446.429
Hs Code.:

Synonyms:Lithium (R)-4-benzyloxy-2-(4-benzyloxycarbonyl-7-oxo-[1,4]diazepan-1-yl)-butyrate

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Chemical Property of Lithium (R)-4-benzyloxy-2-(4-benzyloxycarbonyl-7-oxo-[1,4]diazepan-1-yl)-butyrate

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Technology Process of Lithium (R)-4-benzyloxy-2-(4-benzyloxycarbonyl-7-oxo-[1,4]diazepan-1-yl)-butyrate

There total 6 articles about Lithium (R)-4-benzyloxy-2-(4-benzyloxycarbonyl-7-oxo-[1,4]diazepan-1-yl)-butyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1205542-44-4
4-((S)-3-benzyloxy-1-methoxycarbonyl-propyl)-5-oxo-[1,4]diazepane-1-carboxylic acid benzyl ester

: 1290049-11-4
Lithium (R)-4-benzyloxy-2-(4-benzyloxycarbonyl-7-oxo-[1,4]diazepan-1-yl)-butyrate

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; methanol; at 0 ℃; for 3h;

Reference yield:

: 13139-17-8
N-(Benzyloxycarbonyloxy)succinimide

: 1290049-11-4
Lithium (R)-4-benzyloxy-2-(4-benzyloxycarbonyl-7-oxo-[1,4]diazepan-1-yl)-butyrate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 18 h / 0 - 30 °C

1.2: 3 h / 0 - 20 °C

2.1: triethylamine; oxalyl dichloride; dimethyl sulfoxide / dichloromethane / -60 - -50 °C

3.1: triethylamine; acetic acid; borane pyridine / ethanol; 1,2-dichloro-ethane / 1.25 h / 20 °C

4.1: hydrogenchloride; water / 1,4-dioxane / 12 h / 10 - 20 °C

5.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 15 h / 0 - 20 °C

6.1: water; lithium hydroxide / tetrahydrofuran; methanol / 3 h / 0 °C

With hydrogenchloride; oxalyl dichloride; borane pyridine; water; acetic acid; dimethyl sulfoxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; 1,2-dichloro-ethane;

Reference yield:

: 1205542-41-1
3-[benzyloxycarbonyl-(2-oxo-ethyl)-amino]-propionic acid tert-butyl ester

: 1290049-11-4
Lithium (R)-4-benzyloxy-2-(4-benzyloxycarbonyl-7-oxo-[1,4]diazepan-1-yl)-butyrate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine; acetic acid; borane pyridine / ethanol; 1,2-dichloro-ethane / 1.25 h / 20 °C

2: hydrogenchloride; water / 1,4-dioxane / 12 h / 10 - 20 °C

3: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 15 h / 0 - 20 °C

4: water; lithium hydroxide / tetrahydrofuran; methanol / 3 h / 0 °C

With hydrogenchloride; borane pyridine; water; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; 1,2-dichloro-ethane;