3-methyl-2-{[7-(4-phenylthiazol-2-yl)naphthalene-2-carbonyl]amino}butyric acid

Base Information

Chemical Name:3-methyl-2-{[7-(4-phenylthiazol-2-yl)naphthalene-2-carbonyl]amino}butyric acid
CAS No.:1620738-77-3
Molecular Formula:C₂₅H₂₂N₂O₃S
Molecular Weight:430.527
Hs Code.:

Synonyms:3-methyl-2-{[7-(4-phenylthiazol-2-yl)naphthalene-2-carbonyl]amino}butyric acid

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Chemical Property of 3-methyl-2-{[7-(4-phenylthiazol-2-yl)naphthalene-2-carbonyl]amino}butyric acid

Chemical Property:

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Technology Process of 3-methyl-2-{[7-(4-phenylthiazol-2-yl)naphthalene-2-carbonyl]amino}butyric acid

There total 6 articles about 3-methyl-2-{[7-(4-phenylthiazol-2-yl)naphthalene-2-carbonyl]amino}butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 1620738-96-6
3-methyl-2-{[7-(4-phenylthiazol-2-yl)naphthalene-2-carbonyl]amino}butyric acid methyl ester

: 1620738-77-3
3-methyl-2-{[7-(4-phenylthiazol-2-yl)naphthalene-2-carbonyl]amino}butyric acid

Guidance literature:: With lithium hydroxide monohydrate; In tetrahydrofuran; methanol; water; at 20 ℃; for 1h;

Reference yield:

: 5159-63-7
7-bromo-naphthalene-2-carboxylic acid methyl ester

: 1620738-77-3
3-methyl-2-{[7-(4-phenylthiazol-2-yl)naphthalene-2-carbonyl]amino}butyric acid

Guidance literature:: Multi-step reaction with 5 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 3 h / 100 °C / Inert atmosphere

2: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 5 h / 100 °C / Inert atmosphere

3: lithium hydroxide; water / tetrahydrofuran; methanol / 16 h / 20 °C

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C

5: lithium hydroxide monohydrate / tetrahydrofuran; water; methanol / 1 h / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium hydroxide monohydrate; potassium acetate; water; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; 2: |Suzuki Coupling;

Reference yield:

: 5043-14-1
7-bromonaphthalene-2-carboxylic acid

: 1620738-77-3
3-methyl-2-{[7-(4-phenylthiazol-2-yl)naphthalene-2-carbonyl]amino}butyric acid

Guidance literature:: Multi-step reaction with 6 steps

1: sulfuric acid / 18 h / Reflux

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 3 h / 100 °C / Inert atmosphere

3: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 5 h / 100 °C / Inert atmosphere

4: lithium hydroxide; water / tetrahydrofuran; methanol / 16 h / 20 °C

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C

6: lithium hydroxide monohydrate / tetrahydrofuran; water; methanol / 1 h / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium hydroxide monohydrate; sulfuric acid; potassium acetate; water; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; 3: |Suzuki Coupling;