4-nitrobenzyl (2R,3R)-2-diazo-4-<3-(1-methoxy-1-methylethyl)-4-oxoazetidin-2-yl>-3-oxobutanoate

Base Information

Chemical Name:4-nitrobenzyl (2R,3R)-2-diazo-4-<3-(1-methoxy-1-methylethyl)-4-oxoazetidin-2-yl>-3-oxobutanoate
CAS No.:89063-93-4
Molecular Formula:C₁₈H₂₀N₄O₇
Molecular Weight:404.379
Hs Code.:

Synonyms:4-nitrobenzyl (2R,3R)-2-diazo-4-<3-(1-methoxy-1-methylethyl)-4-oxoazetidin-2-yl>-3-oxobutanoate

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Chemical Property of 4-nitrobenzyl (2R,3R)-2-diazo-4-<3-(1-methoxy-1-methylethyl)-4-oxoazetidin-2-yl>-3-oxobutanoate

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Technology Process of 4-nitrobenzyl (2R,3R)-2-diazo-4-<3-(1-methoxy-1-methylethyl)-4-oxoazetidin-2-yl>-3-oxobutanoate

There total 5 articles about 4-nitrobenzyl (2R,3R)-2-diazo-4-<3-(1-methoxy-1-methylethyl)-4-oxoazetidin-2-yl>-3-oxobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 86541-17-5
(6R)-2,2-dimethyl-3-oxa-1-azabicyclo<4.2.0>octan-8-one

: 89063-93-4
4-nitrobenzyl (2R,3R)-2-diazo-4-<3-(1-methoxy-1-methylethyl)-4-oxoazetidin-2-yl>-3-oxobutanoate

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) n-BuLi, 3.) Ph₃SnH, 4.) HMPA

2: 95 percent / AcOH, H₂O / 0.5 h / 65 °C

3: 79 percent / Jones reagent / acetone / 40 h / Ambient temperature

4: 1.) N,N'-carbonyldiimidazole / 1.) THF, RT, 5 h, 2.) THF, RT, overnight

5: 1.) p-toluenesulfonyl azide, 2.) Et₃N / 1.) MeCN, 0 deg C, 10 min, 2.) MeCN, 0 deg C, 50 min

With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; 4-toluenesulfonyl azide; jones reagent; triphenylstannane; water; acetic acid; triethylamine; 1,1'-carbonyldiimidazole; In acetone;

Reference yield:

: 89001-88-7
(6R,7S)-2,2-dimethyl-7-(1-methoxy-1-methylethyl)-1-aza-3-oxabicyclo<4.2.0.>octan-8-one

: 89063-93-4
4-nitrobenzyl (2R,3R)-2-diazo-4-<3-(1-methoxy-1-methylethyl)-4-oxoazetidin-2-yl>-3-oxobutanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / AcOH, H₂O / 0.5 h / 65 °C

2: 79 percent / Jones reagent / acetone / 40 h / Ambient temperature

3: 1.) N,N'-carbonyldiimidazole / 1.) THF, RT, 5 h, 2.) THF, RT, overnight

4: 1.) p-toluenesulfonyl azide, 2.) Et₃N / 1.) MeCN, 0 deg C, 10 min, 2.) MeCN, 0 deg C, 50 min

With 4-toluenesulfonyl azide; jones reagent; water; acetic acid; triethylamine; 1,1'-carbonyldiimidazole; In acetone;

Reference yield:

: (3R,4S)-4-(2-hydroxyethyl)-3-(1-methoxy-1-methylethyl)azetidin-2-one

: 89063-93-4
4-nitrobenzyl (2R,3R)-2-diazo-4-<3-(1-methoxy-1-methylethyl)-4-oxoazetidin-2-yl>-3-oxobutanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 79 percent / Jones reagent / acetone / 40 h / Ambient temperature

2: 1.) N,N'-carbonyldiimidazole / 1.) THF, RT, 5 h, 2.) THF, RT, overnight

3: 1.) p-toluenesulfonyl azide, 2.) Et₃N / 1.) MeCN, 0 deg C, 10 min, 2.) MeCN, 0 deg C, 50 min

With 4-toluenesulfonyl azide; jones reagent; triethylamine; 1,1'-carbonyldiimidazole; In acetone;