N-benzyloxycarbonyl NFLX

Base Information

• Chemical Name: N-benzyloxycarbonyl NFLX
• CAS No.: 105439-94-9
• Molecular Formula: C₂₄H₂₄FN₃O₅
• Molecular Weight: 453.47
• Mol file: 105439-94-9.mol

Synonyms:N-benzyloxycarbonyl NFLX

Chemical Property of N-benzyloxycarbonyl NFLX

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of N-benzyloxycarbonyl NFLX

There total 1 articles about N-benzyloxycarbonyl NFLX which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

benzyl chloroformate (501-53-1,94274-21-2) + 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid (70458-96-7) → N-benzyloxycarbonyl NFLX (105439-94-9)

Guidance literature:

With sodium hydroxide; for 1h; Ambient temperature;

DOI:10.1248/cpb.33.4870

Reference yield: 69.0%

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one (80715-22-6) + N-benzyloxycarbonyl NFLX (105439-94-9) → N-benzyloxycarbonyl NFLX (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester (105439-93-8)

Guidance literature:

With potassium carbonate; In acetonitrile; at 60 ℃;

DOI:10.1248/cpb.33.4870

Reference yield:

N-benzyloxycarbonyl NFLX (105439-94-9) → C24H23ClFN3O4

Guidance literature:

With thionyl chloride; at 75 ℃; for 10h;

DOI:10.1080/15257770902736442

upstream raw materials:

benzyl chloroformate

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

Downstream raw materials:

N-benzyloxycarbonyl NFLX (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester