2-(3-Chlorophenyl)pyrrolidine

Base Information

Chemical Name:2-(3-Chlorophenyl)pyrrolidine
CAS No.:298690-74-1
Molecular Formula:C10H12ClN
Molecular Weight:181.665
Hs Code.:2933998090
European Community (EC) Number:816-828-8
DSSTox Substance ID:DTXSID50404478
Mol file:298690-74-1.mol

Synonyms:2-(3-chlorophenyl)pyrrolidine;298690-74-1;2-(3-Chloro-phenyl)-pyrrolidine;MFCD02663429;PYRROLIDINE, 2-(3-CHLOROPHENYL)-;(R)-2-(3-Chloro-phenyl)-pyrrolidine;(S)-2-(3-Chloro-phenyl)-pyrrolidine;Oprea1_667378;SCHEMBL166164;DTXSID50404478;SRTPGDGQKPCDMC-UHFFFAOYSA-N;AKOS000153430;AKOS016343539;AB12044;SB31876;SB31884;(RS)-2-(3-chloro-phenyl)-pyrrolidine;AC-28289;AS-30615;SY101308;2-(3-chlorophenyl)pyrrolidine, AldrichCPR;AM20040128;BB 0249493;CS-0171120;FT-0649885;EN300-44297;A26410;J-505777;Z234895217;TERT-BUTYL4-[4-(HYDROXYMETHYL)PHENYL]TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE

Suppliers and Price of 2-(3-Chlorophenyl)pyrrolidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-(3-Chlorophenyl)pyrrolidine
100mg
$ 45.00

J&W Pharmlab
2-(3-Chloro-phenyl)-pyrrolidine 97%
25g
$ 960.00

Crysdot
2-(3-Chlorophenyl)pyrrolidine 97%
10g
$ 444.00

Chemenu
2-(3-Chlorophenyl)pyrrolidine 97%
10g
$ 415.00

Biosynth Carbosynth
2-(3-Chlorophenyl)pyrrolidine
2 g
$ 416.90

Biosynth Carbosynth
2-(3-Chlorophenyl)pyrrolidine
5 g
$ 667.00

Biosynth Carbosynth
2-(3-Chlorophenyl)pyrrolidine
1 g
$ 260.60

AstaTech
2-(3-CHLOROPHENYL)PYRROLIDINE 97%
1 / G
$ 78.00

AstaTech
2-(3-CHLOROPHENYL)PYRROLIDINE 97%
5 / G
$ 280.00

Apolloscientific
2-(3-Chlorophenyl)pyrrolidine 97%
1g
$ 115.00

Total 27 raw suppliers

Chemical Property of 2-(3-Chlorophenyl)pyrrolidine

Chemical Property:

Vapor Pressure:0.00763mmHg at 25°C
Refractive Index:1.548
Boiling Point:260.1 °C at 760 mmHg
PKA:9.58±0.10(Predicted)
Flash Point:111.1 °C
PSA：12.03000
Density:1.129 g/cm³
LogP:3.09330
Storage Temp.:2-8°C(protect from light)
XLogP3:2.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:181.0658271
Heavy Atom Count:12
Complexity:149

Purity/Quality:

99%, ^*data from raw suppliers

2-(3-Chlorophenyl)pyrrolidine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36
Safety Statements: 26

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(NC1)C2=CC(=CC=C2)Cl

Technology Process of 2-(3-Chlorophenyl)pyrrolidine

There total 7 articles about 2-(3-Chlorophenyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 374588-99-5
5-(3-chlorophenyl)-3,4-dihydro-2H-pyrrole

: 298690-74-1,1217756-62-1
(+/-)-2-(3-chlorophenyl)-pyrrolidine

Guidance literature:: With sodium tetrahydroborate; acetic acid; In methanol; at 20 ℃; Cooling with ice;
DOI:10.1016/j.ejmech.2017.02.029

Reference yield:

: 1-[2-(3-chlorophenyl)-1-pyrrolidinyl]-2,2,2-trifluoro-ethanone

: 298690-74-1,1217756-62-1
(+/-)-2-(3-chlorophenyl)-pyrrolidine

Guidance literature:: With potassium hydroxide; In methanol; at 0 - 20 ℃; for 12.1667h; Sealed tube; Inert atmosphere;
DOI:10.1016/j.chempr.2020.02.002

Reference yield:

: 535-80-8
3-chlorobenzoate

: 298690-74-1,1217756-62-1
(+/-)-2-(3-chlorophenyl)-pyrrolidine

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / 2 h / Reflux

2: sodium hydride / tetrahydrofuran / 3 h / Heating

3: hydrogenchloride / tetrahydrofuran; water / Reflux

4: acetic acid; sodium tetrahydroborate / methanol / 20 °C / Cooling with ice

With hydrogenchloride; sodium tetrahydroborate; thionyl chloride; sodium hydride; acetic acid; In tetrahydrofuran; methanol; water;
DOI:10.1016/j.ejmech.2017.02.029