1-(tert-Butoxycarbonyl)azetidine-2-carboxylic acid

Base Information

Chemical Name:1-(tert-Butoxycarbonyl)azetidine-2-carboxylic acid
CAS No.:159749-28-7
Molecular Formula:C9H15NO4
Molecular Weight:201.222
Hs Code.:29339900
European Community (EC) Number:816-638-5
DSSTox Substance ID:DTXSID50394401
Mol file:159749-28-7.mol

Synonyms:159749-28-7;1-(tert-Butoxycarbonyl)azetidine-2-carboxylic acid;Azetidine-1,2-dicarboxylic acid 1-tert-butyl ester;N-Boc-Azetidine-2-carboxylic acid;1-BOC-AZETIDINE-2-CARBOXYLIC ACID;1-[(2-methylpropan-2-yl)oxycarbonyl]azetidine-2-carboxylic Acid;1-[(tert-butoxy)carbonyl]azetidine-2-carboxylic acid;1-N-BOC-AZETIDINE-2-CARBOXYLIC ACID;MFCD01861756;C9H15NO4;(s)-n-boc-azetidine-2-carboxylic acid;1-tert-butoxycarbonylazetidine-2-carboxylic acid;(R)-N-BOC-AZETIDINE-2-CARBOXYLIC ACID;SCHEMBL73360;N-Boc-azetdne-2-carboxylc acd;DTXSID50394401;JWJVSDZKYYXDDN-UHFFFAOYSA-N;n-boc-azetidine-4-carboxylic acid;BCP11462;BCP26489;AC-764;AKOS007930507;AC-7924;AM84527;BOC-AZETIDINE-2-CARBOXYLIC ACID;CS-W018641;PB14242;PB19943;PB24715;AC-26596;DS-11206;SY004654;SY004664;SY004665;FT-0639966;FT-0648960;FT-0684837;EN300-74799;azetidine-1,2-dicarboxylic acid-1-t-butyl ester;1-(tert-Butoxycarbonyl)azetidine-2-carboxylicacid;A810063;1-(tert-Butoxyccarbonyl)azetidine-2-carboxylic acid;J-523511;N-tert-butyloxycarbonylazetidin-2-yl carboxylic acid;Z1171194607;Azetidine-1,2-dicarboxylic acid 1-tert-butyl ester, AldrichCPR;S-2-Benzothiazolyl(Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-methoxyiminothioacetate

Suppliers and Price of 1-(tert-Butoxycarbonyl)azetidine-2-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-(tert-Butoxycarbonyl)azetidine-2-carboxylicAcid
10mg
$ 45.00

Synthonix
1-Boc-Azetidine-2-carboxylicacid 97.0%
25g
$ 350.00

SynQuest Laboratories
1-[(tert-Butoxy)carbonyl]azetidine-2-carboxylic acid 97.0%
1 g
$ 265.00

SynQuest Laboratories
1-[(tert-Butoxy)carbonyl]azetidine-2-carboxylic acid 97.0%
25 g
$ 1290.00

SynQuest Laboratories
1-[(tert-Butoxy)carbonyl]azetidine-2-carboxylic acid 97.0%
5 g
$ 790.00

SynQuest Laboratories
1-[(tert-Butoxy)carbonyl]azetidine-2-carboxylic acid 97.0%
250 mg
$ 115.00

SynChem
AZETIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 95%
1 g
$ 130.00

Frontier Specialty Chemicals
N-Boc-azetidine-2-carboxylicacid 97%
250mg
$ 155.00

Crysdot
1-(tert-Butoxycarbonyl)azetidine-2-carboxylicacid 95+%
10g
$ 164.00

ChemScene
1-(tert-Butoxycarbonyl)azetidine-2-carboxylicacid >97.0%
10g
$ 138.00

Total 51 raw suppliers

Chemical Property of 1-(tert-Butoxycarbonyl)azetidine-2-carboxylic acid

Chemical Property:

Vapor Pressure:6.35E-05mmHg at 25°C
Refractive Index:1.51
Boiling Point:321 °C at 760 mmHg
PKA:4.01±0.20(Predicted)
Flash Point:147.9 °C
PSA：66.84000
Density:1.246 g/cm³
LogP:1.01830
Storage Temp.:2-8°C
XLogP3:0.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:201.10010796
Heavy Atom Count:14
Complexity:256

Purity/Quality:

97% ^*data from raw suppliers

1-(tert-Butoxycarbonyl)azetidine-2-carboxylicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi,N
Statements: 36/37/38-50
Safety Statements: 26-36-61-24/25

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCC1C(=O)O
Uses 1,2-Azetidinedicarboxylic Acid 1-(1,1-Dimethylethyl) Ester, is an useful intermediate in the synthesis of pharmaceutical compounds including inhibitors and receptor Antagonists. It can be used in the synthesis of polypeptides.

Technology Process of 1-(tert-Butoxycarbonyl)azetidine-2-carboxylic acid

There total 7 articles about 1-(tert-Butoxycarbonyl)azetidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 2517-04-6,20063-89-2
Azetidine-2-carboxylic acid

: 159749-28-7
1-(tert-butoxycarbonyl)azetidine-2-carboxylic acid

Guidance literature:: With sodium carbonate; In tetrahydrofuran; water; at 20 ℃;
DOI:10.1021/acs.jmedchem.6b01718

Reference yield: 63.1%

: 24424-99-5
di-tert-butyl dicarbonate

: 2133-34-8,20063-89-2
(2S)-azetidine-2-carboxylic acid

: 159749-28-7
1-(tert-butoxycarbonyl)azetidine-2-carboxylic acid

Guidance literature:: di-tert-butyl dicarbonate; (2S)-azetidine-2-carboxylic acid; With 4-methyl-morpholine; In 1,4-dioxane; water; at 0 - 25 ℃; for 22h;

With hydrogenchloride; In water; at 0 ℃; pH=1;