1-N-Cbz-pyrrolidine-3-carboxylic acid

Base Information

Chemical Name:1-N-Cbz-pyrrolidine-3-carboxylic acid
CAS No.:188527-21-1
Molecular Formula:C13H15 N O4
Molecular Weight:249.266
Hs Code.:2933990090
European Community (EC) Number:675-937-7
DSSTox Substance ID:DTXSID30940349
Nikkaji Number:J1.580.381I
Mol file:188527-21-1.mol

Synonyms:188527-21-1;1-N-Cbz-pyrrolidine-3-carboxylic acid;1-(benzyloxycarbonyl)pyrrolidine-3-carboxylic acid;1-((benzyloxy)carbonyl)pyrrolidine-3-carboxylic acid;n-cbz-pyrrolidine-3-carboxylic acid;1-Cbz-pyrrolidine-3-carboxylic acid;1-[(benzyloxy)carbonyl]pyrrolidine-3-carboxylic acid;1-n-cbz-beta-proline;MFCD02179036;pyrrolidine-1,3-dicarboxylic acid 1-benzyl ester;1-phenylmethoxycarbonylpyrrolidine-3-carboxylic acid;1-N-Cbz-belta-Proline;(R)-N-CBZ-3-PYRROLIDINECARBOXYLIC ACID;1-Cbz-3-pyrrolidinecarboxylic acid;3-carboxy-1-cbz-pyrrolidine;MFCD08692037;MFCD09608053;3-carboxy-1-phenylmethyloxycarbonylpyrrolidine;C67154;1-Cbz-pyrrolidine-3-carboxylicacid;1-benzyloxycarbonylpyrrolidine-3-carboxylic acid;n-cbz-3-carboxy pyrrolidine;SCHEMBL103560;DTXSID30940349;JSASVUTVTRNJHA-UHFFFAOYSA-N;N-Cbz-3-Pyrrolidinecarboxylic Acid;AMY38117;BCP22670;1-N-Cbz-pyrrolidine-3-carboxylicacid;AKOS012305591;BCP9000054;CS-W002897;PB14610;PB20364;PB30728;SB10259;(s)-1-cbz-3-pyrrolidinecarboxylic acid;DS-12581;SY016106;SY020720;SY023067;DB-031528;DB-065769;DB-065770;A4164;N-carbobenzyloxypyrrolidine-3-carboxylic acid;CHLOROPHENOLRED-BETA-D-GALACTOPYRANOSID;EN300-173646;pyrrolidine-1,3-dicarboxylic acid benzyl ester;1-N-cbz-pyrrolidine-3-carboxylic acid, AldrichCPR;Q-102897;W-206376;1-[(benzyloxy)carbonyl]-3-pyrrolidinecarboxylic acid;Z1078654422

Suppliers and Price of 1-N-Cbz-pyrrolidine-3-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-?(Benzyloxycarbonyl)?pyrrolidine-?3-?carboxylicAcid
100mg
$ 50.00

TRC
1-?(Benzyloxycarbonyl)?pyrrolidine-?3-?carboxylicAcid
250mg
$ 70.00

SynQuest Laboratories
1-[(Benzyloxy)carbonyl]pyrrolidine-3-carboxylic acid 97.0%
250 mg
$ 75.00

SynQuest Laboratories
1-[(Benzyloxy)carbonyl]pyrrolidine-3-carboxylic acid 97.0%
1 g
$ 155.00

SynQuest Laboratories
1-[(Benzyloxy)carbonyl]pyrrolidine-3-carboxylic acid 97.0%
25 g
$ 790.00

SynQuest Laboratories
1-[(Benzyloxy)carbonyl]pyrrolidine-3-carboxylic acid 97.0%
5 g
$ 438.00

Matrix Scientific
1-N-Cbz-pyrrolidine-3-carboxylic acid 95+%
5g
$ 559.00

Matrix Scientific
1-N-Cbz-pyrrolidine-3-carboxylic acid 95+%
1g
$ 185.00

Crysdot
1-N-Cbz-Pyrrolidine-3-carboxylicacid 97%
10g
$ 172.00

Chemenu
1-[(benzyloxy)carbonyl]pyrrolidine-3-carboxylicacid 97%
25g
$ 352.00

Total 64 raw suppliers

Chemical Property of 1-N-Cbz-pyrrolidine-3-carboxylic acid

Chemical Property:

Vapor Pressure:3.06E-08mmHg at 25°C
Boiling Point:432.3°Cat760mmHg
PKA:4.46±0.20(Predicted)
Flash Point:215.3°C
PSA：66.84000
Density:1.309g/cm³
LogP:1.66760
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
XLogP3:1.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:249.10010796
Heavy Atom Count:18
Complexity:312

Purity/Quality:

99% ^*data from raw suppliers

1-?(Benzyloxycarbonyl)?pyrrolidine-?3-?carboxylicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 43
Safety Statements: 36/37

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CC1C(=O)O)C(=O)OCC2=CC=CC=C2
Uses 1-?(Benzyloxycarbonyl)?pyrrolidine-?3-?carboxylic Acid is a reagent used in the synthesis of cyclin-dependent kinase 4-inhibitors (CDK4) for cancer treatments. Also used towards the discovery of a potent inhibitor of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer pased upon benzimidazole carboxamide moieties.

Technology Process of 1-N-Cbz-pyrrolidine-3-carboxylic acid

There total 4 articles about 1-N-Cbz-pyrrolidine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%