(S)-9-(benzyloxy)-8-methoxy-12a,13-dihydro-6H-benzo[5,6][1,4]diazepino[1,2-a]indol-6-one

Base Information

Chemical Name:(S)-9-(benzyloxy)-8-methoxy-12a,13-dihydro-6H-benzo[5,6][1,4]diazepino[1,2-a]indol-6-one
CAS No.:1239587-37-1
Molecular Formula:C₂₄H₂₀N₂O₃
Molecular Weight:384.434
Hs Code.:

Synonyms:(S)-9-(benzyloxy)-8-methoxy-12a,13-dihydro-6H-benzo[5,6][1,4]diazepino[1,2-a]indol-6-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-9-(benzyloxy)-8-methoxy-12a,13-dihydro-6H-benzo[5,6][1,4]diazepino[1,2-a]indol-6-one

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of (S)-9-(benzyloxy)-8-methoxy-12a,13-dihydro-6H-benzo[5,6][1,4]diazepino[1,2-a]indol-6-one

There total 11 articles about (S)-9-(benzyloxy)-8-methoxy-12a,13-dihydro-6H-benzo[5,6][1,4]diazepino[1,2-a]indol-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1239587-36-0
(2S)-1-[5-methoxy-2-nitro-4-(phenylmethoxy)-benzoyl]-2-indolinealdehyde

: 1239587-37-1
(S)-9-(benzyloxy)-8-methoxy-12a,13-dihydro-6H-benzo[5,6][1,4]diazepino[1,2-a]indol-6-one

Guidance literature:: (2S)-1-[5-methoxy-2-nitro-4-(phenylmethoxy)-benzoyl]-2-indolinealdehyde; With sodium dithionite; water; In tetrahydrofuran; at 20 ℃; for 18h;

With acetyl chloride; In methanol; at 20 ℃;

With sodium hydrogencarbonate; In methanol; water;

Reference yield:

: 79815-20-6,78348-24-0
(S)-indoline-2-carboxylic acid

: 1239587-37-1
(S)-9-(benzyloxy)-8-methoxy-12a,13-dihydro-6H-benzo[5,6][1,4]diazepino[1,2-a]indol-6-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride / 16 h / 0 - 25 °C / Large scale

2.1: triethylamine / tetrahydrofuran / 0.5 h / 0 - 10 °C / Large scale

2.2: 16 h / 0 - 20 °C / Large scale

3.1: sodium tetrahydroborate; lithium chloride; ethanol / tetrahydrofuran / 16 h / 0 - 20 °C / Large scale

4.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 16 h / 20 °C / Large scale

5.1: iron; ammonium chloride / tetrahydrofuran; methanol; water / 48 h / 20 - 65 °C / Inert atmosphere; Large scale

With sodium tetrahydroborate; thionyl chloride; ethanol; iron; sodium hydrogencarbonate; ammonium chloride; Dess-Martin periodane; triethylamine; lithium chloride; In tetrahydrofuran; methanol; dichloromethane; water;

Reference yield:

: 3943-74-6
4-hydroxy-3-methoxybenzoic acid methyl ester

: 1239587-37-1
(S)-9-(benzyloxy)-8-methoxy-12a,13-dihydro-6H-benzo[5,6][1,4]diazepino[1,2-a]indol-6-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 72 h / 20 °C

2.1: acetic acid; sulfuric acid; nitric acid / 3 h / 0 - 20 °C

3.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 16 h / 20 °C / Large scale

4.1: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran; dichloromethane / 16 h / 0 - 20 °C

5.1: triethylamine / tetrahydrofuran / 0.5 h / 0 - 10 °C / Large scale

5.2: 16 h / 0 - 20 °C / Large scale

6.1: sodium tetrahydroborate; lithium chloride; ethanol / tetrahydrofuran / 16 h / 0 - 20 °C / Large scale

7.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 16 h / 20 °C / Large scale

8.1: iron; ammonium chloride / tetrahydrofuran; methanol; water / 48 h / 20 - 65 °C / Inert atmosphere; Large scale

With sodium tetrahydroborate; oxalyl dichloride; lithium hydroxide monohydrate; ethanol; sulfuric acid; water; nitric acid; iron; sodium hydrogencarbonate; potassium carbonate; ammonium chloride; Dess-Martin periodane; acetic acid; triethylamine; N,N-dimethyl-formamide; lithium chloride; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;