N-[9-(1-benzhydryl-5-hydroxy-6-hydroxymethyl-4-methoxy-piperidin-3-yl)-9H-purin-6-yl]-benzamide

Base Information

Chemical Name:N-[9-(1-benzhydryl-5-hydroxy-6-hydroxymethyl-4-methoxy-piperidin-3-yl)-9H-purin-6-yl]-benzamide
CAS No.:259190-61-9
Molecular Formula:C₃₂H₃₂N₆O₄
Molecular Weight:564.644
Hs Code.:

<i>N</i>-[9-(1-benzhydryl-5-hydroxy-6-hydroxymethyl-4-methoxy-piperidin-3-yl)-9<i>H</i>-purin-6-yl]-benzamide

Synonyms:N-[9-(1-benzhydryl-5-hydroxy-6-hydroxymethyl-4-methoxy-piperidin-3-yl)-9H-purin-6-yl]-benzamide

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Chemical Property of N-[9-(1-benzhydryl-5-hydroxy-6-hydroxymethyl-4-methoxy-piperidin-3-yl)-9H-purin-6-yl]-benzamide

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Technology Process of N-[9-(1-benzhydryl-5-hydroxy-6-hydroxymethyl-4-methoxy-piperidin-3-yl)-9H-purin-6-yl]-benzamide

There total 8 articles about N-[9-(1-benzhydryl-5-hydroxy-6-hydroxymethyl-4-methoxy-piperidin-3-yl)-9H-purin-6-yl]-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 259190-60-8
N-{9-[5-benzhydryl-8-methoxy-2-(4-methoxy-phenyl)-2-methyl-hexahydro-[1,3]dioxino[5,4-b]pyridin-7-yl]-9H-purin-6-yl}-benzamide

: 259190-61-9
N-[9-(1-benzhydryl-5-hydroxy-6-hydroxymethyl-4-methoxy-piperidin-3-yl)-9H-purin-6-yl]-benzamide

Guidance literature:: With acetic acid; at 30 ℃; for 4h;
DOI:10.1016/S0960-894X(99)00619-8

Reference yield:

: 132198-14-2
N-Benzhydryl-1-deoxynojirimycin

: 259190-61-9
N-[9-(1-benzhydryl-5-hydroxy-6-hydroxymethyl-4-methoxy-piperidin-3-yl)-9H-purin-6-yl]-benzamide

Guidance literature:: Multi-step reaction with 8 steps

1: 76 percent / pyridinium p-toluenesulfonate / 20 °C

2: 73 percent / AgNO₃; pyridine / 2 h / 20 °C

3: 94 percent / NaH / 2 h / 20 °C

4: 86 percent / TBAF / 2 h / 20 °C

5: 99 percent / Et₃N / 2 h / 20 °C

6: 50 percent / NaH; 18-crown-6 / 17 h / 100 °C

7: 66 percent / pyridine; NH₄OH

8: 55 percent / 80 percent AcOH / 4 h / 30 °C

With pyridine; ammonium hydroxide; 18-crown-6 ether; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; sodium hydride; silver nitrate; acetic acid; triethylamine; 1: Condensation / 2: silylation / 3: Methylation / 4: desilylation / 5: mesylation / 6: Substitution / 7: Acylation / 8: Hydrolysis;
DOI:10.1016/S0960-894X(99)00619-8

Reference yield:

: 259190-54-0
(4aR,7S,8R,8aR)-5-Benzhydryl-2-(4-methoxy-phenyl)-2-methyl-hexahydro-[1,3]dioxino[5,4-b]pyridine-7,8-diol

: 259190-61-9
N-[9-(1-benzhydryl-5-hydroxy-6-hydroxymethyl-4-methoxy-piperidin-3-yl)-9H-purin-6-yl]-benzamide

Guidance literature:: Multi-step reaction with 7 steps

1: 73 percent / AgNO₃; pyridine / 2 h / 20 °C

2: 94 percent / NaH / 2 h / 20 °C

3: 86 percent / TBAF / 2 h / 20 °C

4: 99 percent / Et₃N / 2 h / 20 °C

5: 50 percent / NaH; 18-crown-6 / 17 h / 100 °C

6: 66 percent / pyridine; NH₄OH

7: 55 percent / 80 percent AcOH / 4 h / 30 °C

With pyridine; ammonium hydroxide; 18-crown-6 ether; tetrabutyl ammonium fluoride; sodium hydride; silver nitrate; acetic acid; triethylamine; 1: silylation / 2: Methylation / 3: desilylation / 4: mesylation / 5: Substitution / 6: Acylation / 7: Hydrolysis;
DOI:10.1016/S0960-894X(99)00619-8