1-(3,5-dichloro-phenyl)-3-(4-{hydroxy-[1-(toluene-4-sulfonyl)-1H-pyrrol-3-yl]-methyl}-benzyl)-urea

Base Information

• Chemical Name: 1-(3,5-dichloro-phenyl)-3-(4-{hydroxy-[1-(toluene-4-sulfonyl)-1H-pyrrol-3-yl]-methyl}-benzyl)-urea
• CAS No.: 466671-46-5
• Molecular Formula: C₂₆H₂₃Cl₂N₃O₄S
• Molecular Weight: 544.458

Synonyms:1-(3,5-dichloro-phenyl)-3-(4-{hydroxy-[1-(toluene-4-sulfonyl)-1H-pyrrol-3-yl]-methyl}-benzyl)-urea

Chemical Property of 1-(3,5-dichloro-phenyl)-3-(4-{hydroxy-[1-(toluene-4-sulfonyl)-1H-pyrrol-3-yl]-methyl}-benzyl)-urea

Chemical Property:

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Technology Process of 1-(3,5-dichloro-phenyl)-3-(4-{hydroxy-[1-(toluene-4-sulfonyl)-1H-pyrrol-3-yl]-methyl}-benzyl)-urea

There total 5 articles about 1-(3,5-dichloro-phenyl)-3-(4-{hydroxy-[1-(toluene-4-sulfonyl)-1H-pyrrol-3-yl]-methyl}-benzyl)-urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-(3,5-dichloro-phenyl)-3-{4-[1-(toluene-4-sulfonyl)-1H-pyrrole-3-carbonyl]-benzyl}-urea (466671-45-4) → 1-(3,5-dichloro-phenyl)-3-(4-{hydroxy-[1-(toluene-4-sulfonyl)-1H-pyrrol-3-yl]-methyl}-benzyl)-urea (466671-46-5)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; methanol;

DOI:10.1016/S0960-894X(02)00055-0

Reference yield:

N-p-toluenesulfonylpyrrole (17639-64-4) → 1-(3,5-dichloro-phenyl)-3-(4-{hydroxy-[1-(toluene-4-sulfonyl)-1H-pyrrol-3-yl]-methyl}-benzyl)-urea (466671-46-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 54 percent / AlCl₃ / 1,2-dichloro-ethane

2: 49 percent / H₂; NH₃ / Raney-Ni / methanol

3: 73 percent / tetrahydrofuran

4: 99 percent / NaBH₄ / methanol; tetrahydrofuran

With sodium tetrahydroborate; aluminium trichloride; ammonia; hydrogen; nickel; In tetrahydrofuran; methanol; 1,2-dichloro-ethane;

DOI:10.1016/S0960-894X(02)00055-0

Reference yield:

4-cyanobenzoyl chlorIde (6068-72-0) → 1-(3,5-dichloro-phenyl)-3-(4-{hydroxy-[1-(toluene-4-sulfonyl)-1H-pyrrol-3-yl]-methyl}-benzyl)-urea (466671-46-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 54 percent / AlCl₃ / 1,2-dichloro-ethane

2: 49 percent / H₂; NH₃ / Raney-Ni / methanol

3: 73 percent / tetrahydrofuran

4: 99 percent / NaBH₄ / methanol; tetrahydrofuran

With sodium tetrahydroborate; aluminium trichloride; ammonia; hydrogen; nickel; In tetrahydrofuran; methanol; 1,2-dichloro-ethane;

DOI:10.1016/S0960-894X(02)00055-0

upstream raw materials:

1-(3,5-dichloro-phenyl)-3-{4-[1-(toluene-4-sulfonyl)-1H-pyrrole-3-carbonyl]-benzyl}-urea

N-p-toluenesulfonylpyrrole

4-cyanobenzoyl chlorIde

4-[1-(toluene-4-sulfonyl)-1H-pyrrole-3-carbonyl]-benzonitrile

Downstream raw materials:

1-(3,5-dichloro-phenyl)-3-{4-[1-(toluene-4-sulfonyl)-1H-pyrrol-3-ylmethyl]-benzyl}-urea

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