(S)-4-(Bromomethyl-dimethyl-silanyloxy)-2-methylene-4-phenyl-butyric acid ethyl ester

Base Information

Chemical Name:(S)-4-(Bromomethyl-dimethyl-silanyloxy)-2-methylene-4-phenyl-butyric acid ethyl ester
CAS No.:719301-84-5
Molecular Formula:C₁₆H₂₃BrO₃Si
Molecular Weight:371.346
Hs Code.:

Synonyms:(S)-4-(Bromomethyl-dimethyl-silanyloxy)-2-methylene-4-phenyl-butyric acid ethyl ester

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Chemical Property of (S)-4-(Bromomethyl-dimethyl-silanyloxy)-2-methylene-4-phenyl-butyric acid ethyl ester

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Technology Process of (S)-4-(Bromomethyl-dimethyl-silanyloxy)-2-methylene-4-phenyl-butyric acid ethyl ester

There total 1 articles about (S)-4-(Bromomethyl-dimethyl-silanyloxy)-2-methylene-4-phenyl-butyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 16532-02-8
bromomethyldimethylsilyl chloride

: 109907-81-5,98061-48-4
ethyl 4-hydroxy-2-methylene-4-phenylbutanoate

: 719301-84-5
(S)-4-(Bromomethyl-dimethyl-silanyloxy)-2-methylene-4-phenyl-butyric acid ethyl ester

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 0 ℃;
DOI:10.1016/j.tetlet.2004.03.188

Reference yield: 97.0%

: 719301-84-5
(S)-4-(Bromomethyl-dimethyl-silanyloxy)-2-methylene-4-phenyl-butyric acid ethyl ester

: (R)-2,2-Dimethyl-7-phenyl-[1,2]oxasilepane-5-carboxylic acid ethyl ester

Guidance literature:: (S)-4-(Bromomethyl-dimethyl-silanyloxy)-2-methylene-4-phenyl-butyric acid ethyl ester; With triethyl borane; tri-n-butyl-tin hydride; In tetrahydrofuran; at 0 ℃; for 2h;

With potassium fluoride; In tetrahydrofuran; water; at 20 ℃; for 3h; Further stages.;
DOI:10.1016/j.tetlet.2004.03.188

Reference yield:

: 719301-84-5
(S)-4-(Bromomethyl-dimethyl-silanyloxy)-2-methylene-4-phenyl-butyric acid ethyl ester

: 5-phenyl-3-(hydroxymethyl)pentane-1,5-diol

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-Bu₃SnH; Et₃B / tetrahydrofuran / 2 h / 0 °C

1.2: 97 percent / KF / tetrahydrofuran; H₂O / 3 h / 20 °C

2.1: 85 percent / diisobutylaluminum hydride / CH₂Cl₂ / -50 °C

3.1: 80 percent / aq. H₂O₂; KF; KHCO₃ / methanol; tetrahydrofuran / 20 °C

With potassium fluoride; triethyl borane; dihydrogen peroxide; tri-n-butyl-tin hydride; diisobutylaluminium hydride; potassium hydrogencarbonate; In tetrahydrofuran; methanol; dichloromethane; 3.1: Tamao oxidation;
DOI:10.1016/j.tetlet.2004.03.188