tert-butyl (2-{1-oxo-6-(thiophen-3-yl)-7-[3-(trifluoromethoxy)phenyl]-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl}ethyl)carbamate

Base Information

Chemical Name:tert-butyl (2-{1-oxo-6-(thiophen-3-yl)-7-[3-(trifluoromethoxy)phenyl]-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl}ethyl)carbamate
CAS No.:1429501-38-1
Molecular Formula:C₂₅H₂₆F₃N₃O₄S
Molecular Weight:521.56
Hs Code.:

Synonyms:tert-butyl (2-{1-oxo-6-(thiophen-3-yl)-7-[3-(trifluoromethoxy)phenyl]-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl}ethyl)carbamate

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Chemical Property of tert-butyl (2-{1-oxo-6-(thiophen-3-yl)-7-[3-(trifluoromethoxy)phenyl]-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl}ethyl)carbamate

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Technology Process of tert-butyl (2-{1-oxo-6-(thiophen-3-yl)-7-[3-(trifluoromethoxy)phenyl]-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl}ethyl)carbamate

There total 8 articles about tert-butyl (2-{1-oxo-6-(thiophen-3-yl)-7-[3-(trifluoromethoxy)phenyl]-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl}ethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 6165-69-1
Thien-3-ylboronic acid

: 1429501-08-5
tert-butyl (2-{6-iodo-1-oxo-7-[3-(trifluoromethoxy)phenyl]-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl}ethyl)carbamate

: 1429501-38-1
tert-butyl (2-{1-oxo-6-(thiophen-3-yl)-7-[3-(trifluoromethoxy)phenyl]-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl}ethyl)carbamate

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; In 1,4-dioxane; water; at 80 ℃; for 1h; Inert atmosphere; Sealed tube;

Reference yield:

: 1429500-92-4
4-(2-azidoethyl)-7-[3-(trifluoromethoxy)phenyl]-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one

: 1429501-38-1
tert-butyl (2-{1-oxo-6-(thiophen-3-yl)-7-[3-(trifluoromethoxy)phenyl]-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl}ethyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium chloride; zinc / ethanol / 4 h / 80 °C

2: iodine; silver trifluoroacetate / dichloromethane / 2 h / 5 - 20 °C

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / 1,4-dioxane; water / 1 h / 80 °C / Inert atmosphere; Sealed tube

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; iodine; silver trifluoroacetate; ammonium chloride; caesium carbonate; zinc; In 1,4-dioxane; ethanol; dichloromethane; water;

Reference yield:

: 1429500-89-9
2-{1-oxo-7-[3-(trifluoromethoxy)phenyl]-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl}ethyl methanesulfonate

: 1429501-38-1
tert-butyl (2-{1-oxo-6-(thiophen-3-yl)-7-[3-(trifluoromethoxy)phenyl]-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl}ethyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium azide / N,N-dimethyl-formamide; acetonitrile / 18 h / 80 °C

2: ammonium chloride; zinc / ethanol / 4 h / 80 °C

3: iodine; silver trifluoroacetate / dichloromethane / 2 h / 5 - 20 °C

4: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / 1,4-dioxane; water / 1 h / 80 °C / Inert atmosphere; Sealed tube

With sodium azide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; iodine; silver trifluoroacetate; ammonium chloride; caesium carbonate; zinc; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;