2-[2-(2-Fluoro-ethoxy)-4-methoxy-benzylsulfanyl]-N-pyridin-4-yl-nicotinamide

Base Information

Chemical Name:2-[2-(2-Fluoro-ethoxy)-4-methoxy-benzylsulfanyl]-N-pyridin-4-yl-nicotinamide
CAS No.:181823-95-0
Molecular Formula:C₂₁H₂₀FN₃O₃S
Molecular Weight:413.473
Hs Code.:

Synonyms:2-[2-(2-Fluoro-ethoxy)-4-methoxy-benzylsulfanyl]-N-pyridin-4-yl-nicotinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-[2-(2-Fluoro-ethoxy)-4-methoxy-benzylsulfanyl]-N-pyridin-4-yl-nicotinamide

Chemical Property:

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Technology Process of 2-[2-(2-Fluoro-ethoxy)-4-methoxy-benzylsulfanyl]-N-pyridin-4-yl-nicotinamide

There total 6 articles about 2-[2-(2-Fluoro-ethoxy)-4-methoxy-benzylsulfanyl]-N-pyridin-4-yl-nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5446-02-6
4-methoxymethylsalicylate

: 181823-95-0
2-[2-(2-Fluoro-ethoxy)-4-methoxy-benzylsulfanyl]-N-pyridin-4-yl-nicotinamide

Guidance literature:: Multi-step reaction with 5 steps

1: K₂CO₃ / dimethylformamide / 48 h / 90 °C

2: LiAlH₄ / diethyl ether / 0.5 h / 0 °C

3: 91 percent / conc. HCl

4: oxalyl chloride

With hydrogenchloride; lithium aluminium tetrahydride; oxalyl dichloride; potassium carbonate; In diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/jm9605593

Reference yield:

: 186688-12-0
2-(2-Fluoro-ethoxy)-4-methoxy-benzoic acid methyl ester

: 181823-95-0
2-[2-(2-Fluoro-ethoxy)-4-methoxy-benzylsulfanyl]-N-pyridin-4-yl-nicotinamide

Guidance literature:: Multi-step reaction with 4 steps

1: LiAlH₄ / diethyl ether / 0.5 h / 0 °C

2: 91 percent / conc. HCl

3: oxalyl chloride

With hydrogenchloride; lithium aluminium tetrahydride; oxalyl dichloride; In diethyl ether;
DOI:10.1021/jm9605593

Reference yield:

: 38521-46-9
3-carboxy-2-mercaptopyridine

: 181823-95-0
2-[2-(2-Fluoro-ethoxy)-4-methoxy-benzylsulfanyl]-N-pyridin-4-yl-nicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / conc. HCl

2: oxalyl chloride

With hydrogenchloride; oxalyl dichloride;
DOI:10.1021/jm9605593