N-(N-methyltaurine) N'-α-(L-prolyl-L-phenylalanyl)-N^α-methyl-L-histidyl>-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-methyloctanoyl>-L-isoleucyl>(1-oxo-2-pyridyl)methylamine> octanedioic acid diamide sodium salt

Base Information

• Chemical Name: N-(N-methyltaurine) N'-α-(L-prolyl-L-phenylalanyl)-N^α-methyl-L-histidyl>-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-methyloctanoyl>-L-isoleucyl>(1-oxo-2-pyridyl)methylamine> octanedioic acid diamide sodium salt
• CAS No.: 131064-24-9
• Molecular Formula: C₅₆H₈₅N₁₀O₁₂S*Na
• Molecular Weight: 1145.41

Synonyms:N-(N-methyltaurine) N'-α-(L-prolyl-L-phenylalanyl)-N^α-methyl-L-histidyl>-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-methyloctanoyl>-L-isoleucyl>(1-oxo-2-pyridyl)methylamine> octanedioic acid diamide sodium salt

Chemical Property of N-(N-methyltaurine) N'-α-(L-prolyl-L-phenylalanyl)-N^α-methyl-L-histidyl>-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-methyloctanoyl>-L-isoleucyl>(1-oxo-2-pyridyl)methylamine> octanedioic acid diamide sodium salt

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

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Technology Process of N-(N-methyltaurine) N'-α-(L-prolyl-L-phenylalanyl)-N^α-methyl-L-histidyl>-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-methyloctanoyl>-L-isoleucyl>(1-oxo-2-pyridyl)methylamine> octanedioic acid diamide sodium salt

There total 3 articles about N-(N-methyltaurine) N'-α-(L-prolyl-L-phenylalanyl)-N^α-methyl-L-histidyl>-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-methyloctanoyl>-L-isoleucyl>(1-oxo-2-pyridyl)methylamine> octanedioic acid diamide sodium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

suleptanic acid triethylamine salt (121838-84-4) + (S)-Pyrrolidine-2-carboxylic acid ((S)-1-{[(S)-1-((1S,2S,4S)-2-hydroxy-1-isobutyl-5-methyl-4-{(1S,2S)-2-methyl-1-[methyl-(1-oxy-pyridin-2-yl)-carbamoyl]-butylcarbamoyl}-hexylcarbamoyl)-2-(1H-imidazol-4-yl)-ethyl]-methyl-carbamoyl}-2-phenyl-ethyl)-amide → N-(N-methyltaurine) N'-α-(L-prolyl-L-phenylalanyl)-Nα-methyl-L-histidyl>-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-methyloctanoyl>-L-isoleucyl>(1-oxo-2-pyridyl)methylamine> octanedioic acid diamide sodium salt (131064-24-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; diethyl cyano phosphate; In dichloromethane; acetonitrile; for 18h;

DOI:10.1021/jm00106a026

Reference yield:

N-α--L-phenylalanyl>-Nα-methyl-Nim-tosyl-L-histidyl>-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-methyloctanoyl>-L-isoleucyl>(1-oxo-2-pyridyl)methylamine (130985-35-2) → N-(N-methyltaurine) N'-α-(L-prolyl-L-phenylalanyl)-Nα-methyl-L-histidyl>-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-methyloctanoyl>-L-isoleucyl>(1-oxo-2-pyridyl)methylamine> octanedioic acid diamide sodium salt (131064-24-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 80 percent / 1-hydroxybenzotriazole / methanol / 4 h

2: 127 mg / trifluoroacetic acid / CH₂Cl₂ / 1 h

3: 90 percent / diisopropylethylamine, diethyl phosphorocyanate / CH₂Cl₂; acetonitrile / 18 h

With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; diethyl cyano phosphate; trifluoroacetic acid; In methanol; dichloromethane; acetonitrile;

DOI:10.1021/jm00106a026

Reference yield:

N-α--L-phenylalanyl>-Nα-methyl-Nim-tosyl-L-histidyl>-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-methyloctanoyl>-L-isoleucyl>-2-pyridylmethylamine (130985-34-1) → N-(N-methyltaurine) N'-α-(L-prolyl-L-phenylalanyl)-Nα-methyl-L-histidyl>-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-methyloctanoyl>-L-isoleucyl>(1-oxo-2-pyridyl)methylamine> octanedioic acid diamide sodium salt (131064-24-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 72 percent / NaHCO₃, m-chloroperbenzoic acid / CH₂Cl₂ / 1 h

2: 80 percent / 1-hydroxybenzotriazole / methanol / 4 h

3: 127 mg / trifluoroacetic acid / CH₂Cl₂ / 1 h

4: 90 percent / diisopropylethylamine, diethyl phosphorocyanate / CH₂Cl₂; acetonitrile / 18 h

With sodium hydrogencarbonate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; diethyl cyano phosphate; trifluoroacetic acid; In methanol; dichloromethane; acetonitrile;

DOI:10.1021/jm00106a026

upstream raw materials:

suleptanic acid triethylamine salt

N-α--L-phenylalanyl>-N^α-methyl-N^im-tosyl-L-histidyl>-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-methyloctanoyl>-L-isoleucyl>-2-pyridylmethylamine

N-α--L-phenylalanyl>-N^α-methyl-N^im-tosyl-L-histidyl>-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-methyloctanoyl>-L-isoleucyl>(1-oxo-2-pyridyl)methylamine

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