(S)-N-(4-chloro-2-(2-(5-chloro-7-methylpyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carbonyl)phenyl)methanesulfonamide

Base Information

Chemical Name:(S)-N-(4-chloro-2-(2-(5-chloro-7-methylpyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carbonyl)phenyl)methanesulfonamide
CAS No.:1353628-60-0
Molecular Formula:C₂₀H₂₁Cl₂N₅O₃S
Molecular Weight:482.39
Hs Code.:

Synonyms:(S)-N-(4-chloro-2-(2-(5-chloro-7-methylpyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carbonyl)phenyl)methanesulfonamide

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Chemical Property of (S)-N-(4-chloro-2-(2-(5-chloro-7-methylpyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carbonyl)phenyl)methanesulfonamide

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Technology Process of (S)-N-(4-chloro-2-(2-(5-chloro-7-methylpyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carbonyl)phenyl)methanesulfonamide

There total 6 articles about (S)-N-(4-chloro-2-(2-(5-chloro-7-methylpyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carbonyl)phenyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1353631-59-0
C₁₂H₁₅ClN₄*ClH

: 89979-12-4
5-chloro-2-(methylsulfonamido)benzoic acid

: 1353628-60-0
(S)-N-(4-chloro-2-(2-(5-chloro-7-methylpyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carbonyl)phenyl)methanesulfonamide

Guidance literature:: 5-chloro-2-(methylsulfonamido)benzoic acid; With HATU; In N,N-dimethyl-formamide; for 1h;

C₁₂H₁₅ClN₄*ClH; With triethylamine; In N,N-dimethyl-formamide; for 16h;

Reference yield:

: 26250-84-0
(S)-(-)-1-(tert-butoxycarbonyl)-2-piperidinecarboxylic acid

: 1353628-60-0
(S)-N-(4-chloro-2-(2-(5-chloro-7-methylpyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carbonyl)phenyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 4 h

2.1: sodium bis(trimethylsilyl)amide / tetrahydrofuran; hexanes / -78 - -40 °C

2.2: -78 - -40 °C

2.3: -78 - 20 °C

3.1: hydrazinium monoacetate / ethanol / 16 h / 20 °C

4.1: caesium carbonate / N,N-dimethyl-formamide / 48 h / 110 °C

5.1: trichlorophosphate / 1 h / 110 °C

5.2: 0.5 h / 0 °C

6.1: HATU / N,N-dimethyl-formamide / 1 h

6.2: 16 h

With sodium bis(trimethylsilyl)amide; hydrazinium monoacetate; caesium carbonate; HATU; trichlorophosphate; In tetrahydrofuran; hexanes; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 203056-27-3
tert-butyl (2S)-2-{[methoxy(methyl)amino]-carbonyl}piperidine-1-carboxylate

: 1353628-60-0
(S)-N-(4-chloro-2-(2-(5-chloro-7-methylpyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carbonyl)phenyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium bis(trimethylsilyl)amide / tetrahydrofuran / 0.42 h / -78 - -20 °C / Inert atmosphere

1.2: 3.08 h / -78 - -45 °C

1.3: -78 - 20 °C

2.1: hydrazinium monoacetate / ethanol / 16 h / 20 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 48 h / 110 °C

4.1: trichlorophosphate / 1 h / 110 °C

4.2: 0.5 h / 0 °C

5.1: HATU / N,N-dimethyl-formamide / 1 h

5.2: 16 h

With sodium bis(trimethylsilyl)amide; hydrazinium monoacetate; caesium carbonate; HATU; trichlorophosphate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;