3-[(1S,2R)-6,7-dimethoxy-2-methyl-1-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydro-2-isoquinolinio]propyl-1-sulfate

Base Information

• Chemical Name: 3-[(1S,2R)-6,7-dimethoxy-2-methyl-1-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydro-2-isoquinolinio]propyl-1-sulfate
• CAS No.: 213999-54-3
• Molecular Formula: C₂₄H₃₃NO₉S
• Molecular Weight: 511.593
• Mol file: 213999-54-3.mol

Synonyms:3-[(1S,2R)-6,7-dimethoxy-2-methyl-1-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydro-2-isoquinolinio]propyl-1-sulfate

Chemical Property of 3-[(1S,2R)-6,7-dimethoxy-2-methyl-1-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydro-2-isoquinolinio]propyl-1-sulfate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[(1S,2R)-6,7-dimethoxy-2-methyl-1-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydro-2-isoquinolinio]propyl-1-sulfate

There total 2 articles about 3-[(1S,2R)-6,7-dimethoxy-2-methyl-1-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydro-2-isoquinolinio]propyl-1-sulfate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

(1S)-6,7-dimethoxy-2-methyl-1-(2,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydroisoquinoline (22325-16-2) + 1,3,2-dioxathiane 2,2-dioxide (1073-05-8) → 3-[(1S,2R)-6,7-dimethoxy-2-methyl-1-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydro-2-isoquinolinio]propyl-1-sulfate (213999-54-3)

Guidance literature:

In acetonitrile; at 65 ℃; for 5h;

DOI:10.1021/ol9911573

Reference yield:

(1S)-6,7-dimethoxy-1-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydroisoquinolinium formate → 3-[(1S,2R)-6,7-dimethoxy-2-methyl-1-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydro-2-isoquinolinio]propyl-1-sulfate (213999-54-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / formic acid / 2 h / 100 °C

2: 60 percent / acetonitrile / 5 h / 65 °C

With formic acid; In acetonitrile; 1: Eschweiler-Clarke methylation;

DOI:10.1021/ol9911573

Reference yield: 98.0%

3-[(1S,2R)-6,7-dimethoxy-2-methyl-1-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydro-2-isoquinolinio]propyl-1-sulfate (213999-54-3) → (1S,2R)-6,7-dimethoxy-2-(3-hydroxypropyl)-2-methyl-1-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydroisoquinolinium chloride

Guidance literature:

With methanol; acetyl chloride; at 20 ℃; for 6h;

DOI:10.1021/ol9911573

upstream raw materials:

(1S)-6,7-dimethoxy-2-methyl-1-(2,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydroisoquinoline

1,3,2-dioxathiane 2,2-dioxide