2-(ethoxycarbonyl)-1-(1-formyl-2-phenylethyl)-1,2-dihydroisoquinoline

Base Information

• Chemical Name: 2-(ethoxycarbonyl)-1-(1-formyl-2-phenylethyl)-1,2-dihydroisoquinoline
• CAS No.: 345649-79-8
• Molecular Formula: C₂₁H₂₁NO₃
• Molecular Weight: 335.403
• Mol file: 345649-79-8.mol

Synonyms:2-(ethoxycarbonyl)-1-(1-formyl-2-phenylethyl)-1,2-dihydroisoquinoline

Chemical Property of 2-(ethoxycarbonyl)-1-(1-formyl-2-phenylethyl)-1,2-dihydroisoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(ethoxycarbonyl)-1-(1-formyl-2-phenylethyl)-1,2-dihydroisoquinoline

There total 4 articles about 2-(ethoxycarbonyl)-1-(1-formyl-2-phenylethyl)-1,2-dihydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

1-(trimethyl-silyloxy)-3-phenyl-1-propene (51075-22-0) + 2-(ethoxycarbonyl)isoquinolinium chloride (81357-89-3) → 2-(ethoxycarbonyl)-1-(1-formyl-2-phenylethyl)-1,2-dihydroisoquinoline (345649-79-8)

Guidance literature:

In acetonitrile; at 30 - 40 ℃; for 2.5h;

DOI:10.1246/cl.1983.39

Reference yield:

isoquinoline (119-65-3) → 2-(ethoxycarbonyl)-1-(1-formyl-2-phenylethyl)-1,2-dihydroisoquinoline (345649-79-8)

Guidance literature:

Multi-step reaction with 2 steps

1: acetonitrile / 0 °C

2: 63 percent / acetonitrile / 2.5 h / 30 - 40 °C

In acetonitrile;

DOI:10.1246/cl.1983.39

Reference yield:

2-Acetyl-isoquinolinium; chloride (81357-90-6) → 2-(ethoxycarbonyl)-1-(1-formyl-2-phenylethyl)-1,2-dihydroisoquinoline (345649-79-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 98 percent / acetonitrile / 1.5 h / Ambient temperature

2: 31 percent / diethyl ether / 4 h / Heating

3: acetonitrile / 0 °C

4: 63 percent / acetonitrile / 2.5 h / 30 - 40 °C

In diethyl ether; acetonitrile;

DOI:10.1246/cl.1983.39

upstream raw materials:

1-(trimethyl-silyloxy)-3-phenyl-1-propene

2-(ethoxycarbonyl)isoquinolinium chloride

isoquinoline

2-Acetyl-isoquinolinium; chloride