(2R)-3-[4-(aminomethyl)phenyl]-2-[(tert-butoxy)carbonylamino]propanoic acid trifluoroacetic acid salt

Base Information

• Chemical Name: (2R)-3-[4-(aminomethyl)phenyl]-2-[(tert-butoxy)carbonylamino]propanoic acid trifluoroacetic acid salt
• CAS No.: 1173158-90-1
• Molecular Formula: C₂HF₃O₂*C₁₅H₂₂N₂O₄
• Molecular Weight: 408.375
• Mol file: 1173158-90-1.mol

Synonyms:(2R)-3-[4-(aminomethyl)phenyl]-2-[(tert-butoxy)carbonylamino]propanoic acid trifluoroacetic acid salt

Chemical Property of (2R)-3-[4-(aminomethyl)phenyl]-2-[(tert-butoxy)carbonylamino]propanoic acid trifluoroacetic acid salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R)-3-[4-(aminomethyl)phenyl]-2-[(tert-butoxy)carbonylamino]propanoic acid trifluoroacetic acid salt

There total 1 articles about (2R)-3-[4-(aminomethyl)phenyl]-2-[(tert-butoxy)carbonylamino]propanoic acid trifluoroacetic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trifluoroacetic acid (76-05-1) + (2R)-2-[(tert-butoxy)carbonylamino]-3-(4-cyanophenyl)propanoic acid (146727-62-0) → (2R)-3-[4-(aminomethyl)phenyl]-2-[(tert-butoxy)carbonylamino]propanoic acid trifluoroacetic acid salt (1173158-90-1)

Guidance literature:

(2R)-2-[(tert-butoxy)carbonylamino]-3-(4-cyanophenyl)propanoic acid; With ammonia; hydrogen; Raney Ni; In methanol; water; at 22 ℃; for 4h; under 2585.81 Torr; Parr apparatus;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

(2R)-3-[4-(aminomethyl)phenyl]-2-[(tert-butoxy)carbonylamino]propanoic acid trifluoroacetic acid salt (1173158-90-1) + 1,4,7-tris(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane-10-acetic acid (137076-54-1) → C43H72N6O11 (1173158-92-3)

Guidance literature:

1,4,7-tris(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane-10-acetic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 22 ℃; for 0.5h;

(2R)-3-[4-(aminomethyl)phenyl]-2-[(tert-butoxy)carbonylamino]propanoic acid trifluoroacetic acid salt; In N,N-dimethyl-formamide; for 0.5h;

Reference yield:

(2R)-3-[4-(aminomethyl)phenyl]-2-[(tert-butoxy)carbonylamino]propanoic acid trifluoroacetic acid salt (1173158-90-1) → C44H75N7O11

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.5 h / 22 °C

1.2: 0.5 h

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.5 h

2.2: 1 h

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide;

upstream raw materials:

trifluoroacetic acid

(2R)-2-[(tert-butoxy)carbonylamino]-3-(4-cyanophenyl)propanoic acid

Downstream raw materials:

C₄₃H₇₂N₆O₁₁

2-(4-{[N-({4-[(2R)-2-amino-2-(N-methoxycarbamoyl)ethyl]phenyl}methyl)carbamoyl]methyl}-1,4,7,10-tetraaza-7,10-bis(carboxymethyl)cyclododecyl)acetic acid trifluoroacetic acid salt

C₅₀H₇₉N₇O₁₁

2-[7-({N-[(4-{(2R)-2-amino-2-[N-(phenylmethoxy)carbamoyl]ethyl}phenyl)methyl]carbamoyl}methyl)-1,4,7,10-tetraaza-4,10-bis(carboxymethyl)cyclododecyl]acetic acid trifluoroacetic acid salt

Refernces

• 1、 -. "N-ALKOXYAMIDE CONJUGATES AS IMAGING AGENTS". Page/Page column 115. . Retrieved 2011/02/24.