tert-butyl 3-(2-(1,3-dioxoisoindolin-2-yl)-3-ethoxy-3-oxopropyl)-2-oxo-3-phenylindoline-1-carboxylate

Base Information

Chemical Name:tert-butyl 3-(2-(1,3-dioxoisoindolin-2-yl)-3-ethoxy-3-oxopropyl)-2-oxo-3-phenylindoline-1-carboxylate
CAS No.:1289108-15-1
Molecular Formula:C₃₂H₃₀N₂O₇
Molecular Weight:554.599
Hs Code.:

Synonyms:tert-butyl 3-(2-(1,3-dioxoisoindolin-2-yl)-3-ethoxy-3-oxopropyl)-2-oxo-3-phenylindoline-1-carboxylate

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Chemical Property of tert-butyl 3-(2-(1,3-dioxoisoindolin-2-yl)-3-ethoxy-3-oxopropyl)-2-oxo-3-phenylindoline-1-carboxylate

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Technology Process of tert-butyl 3-(2-(1,3-dioxoisoindolin-2-yl)-3-ethoxy-3-oxopropyl)-2-oxo-3-phenylindoline-1-carboxylate

There total 14 articles about tert-butyl 3-(2-(1,3-dioxoisoindolin-2-yl)-3-ethoxy-3-oxopropyl)-2-oxo-3-phenylindoline-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 862906-97-6
tert-butyl 2-oxo-3-phenylindoline-1-carboxylate

: 24249-89-6
ethyl 2-(1,3-dioxoisoindolin-2-yl)acrylate

: tert-butyl 3-(2-(1,3-dioxoisoindolin-2-yl)-3-ethoxy-3-oxopropyl)-2-oxo-3-phenylindoline-1-carboxylate

: 1289108-15-1
tert-butyl 3-(2-(1,3-dioxoisoindolin-2-yl)-3-ethoxy-3-oxopropyl)-2-oxo-3-phenylindoline-1-carboxylate

Guidance literature:: With epiCDT; In toluene; at 20 ℃; for 10h; optical yield given as %ee; enantioselective reaction;
DOI:10.1021/ol200550y

Reference yield:

: 862906-97-6
tert-butyl 2-oxo-3-phenylindoline-1-carboxylate

: 24249-89-6
ethyl 2-(1,3-dioxoisoindolin-2-yl)acrylate

: tert-butyl 3-(2-(1,3-dioxoisoindolin-2-yl)-3-ethoxy-3-oxopropyl)-2-oxo-3-phenylindoline-1-carboxylate

: 1289108-68-4
tert-butyl 3-(2-(1,3-dioxoisoindolin-2-yl)-3-ethoxy-3-oxopropyl)-2-oxo-3-phenylindoline-1-carboxylate

: 1289108-15-1
tert-butyl 3-(2-(1,3-dioxoisoindolin-2-yl)-3-ethoxy-3-oxopropyl)-2-oxo-3-phenylindoline-1-carboxylate

Guidance literature:: With epiCDT; In dichloromethane; at 20 ℃; for 72h; optical yield given as %ee; enantioselective reaction;
DOI:10.1021/ol200550y

Reference yield:

: 862907-25-3
1-(tert-butoxycarbonyl)-2-oxo-3-phenylindolin-3-yl tert-butyl carbonate

: tert-butyl 3-(2-(1,3-dioxoisoindolin-2-yl)-3-ethoxy-3-oxopropyl)-2-oxo-3-phenylindoline-1-carboxylate

: 1289108-15-1
tert-butyl 3-(2-(1,3-dioxoisoindolin-2-yl)-3-ethoxy-3-oxopropyl)-2-oxo-3-phenylindoline-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: palladium on carbon; hydrogen / methanol / 20 °C

2: epiCDT / toluene / 10 h / 20 °C

With epiCDT; palladium on carbon; hydrogen; In methanol; toluene;
DOI:10.1021/ol200550y