Technology Process of bis(11-benzenesulfonyl-11,12-dihydroretinyl) sulfone
There total 6 articles about bis(11-benzenesulfonyl-11,12-dihydroretinyl) sulfone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
phthalic anhydride; urea-hydrogen peroxide;
In
acetonitrile;
at 0 ℃;
for 1h;
DOI:10.1021/jo990987r
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: Na2S*9H2O / methanol / 10 h / 20 °C
2.1: 7.43 g / HCl / methanol / 1 h / 20 °C
3.1: LiAlH4 / tetrahydrofuran / 1 h / 0 °C
4.1: 9.26 g / PPh3; CCl4 / acetonitrile / 5 h / 20 °C
5.1: NaH / tetrahydrofuran / 0.25 h / 20 °C
5.2: 85 percent / NaI / tetrahydrofuran / 15 h / 20 °C
6.1: 72 percent / urea-hydrogen peroxide; phthalic anhydride / acetonitrile / 1 h / 0 °C
With
hydrogenchloride; tetrachloromethane; sodium sulfide; lithium aluminium tetrahydride; phthalic anhydride; urea-hydrogen peroxide; sodium hydride; triphenylphosphine;
In
tetrahydrofuran; methanol; acetonitrile;
1.1: coupling / 2.1: Hydrolysis / 3.1: Reduction / 4.1: Chlorination / 5.1: Metallation / 5.2: coupling; Julia reaction / 6.1: Oxidation;
DOI:10.1021/jo990987r
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: LiAlH4 / tetrahydrofuran / 1 h / 0 °C
2.1: 9.26 g / PPh3; CCl4 / acetonitrile / 5 h / 20 °C
3.1: NaH / tetrahydrofuran / 0.25 h / 20 °C
3.2: 85 percent / NaI / tetrahydrofuran / 15 h / 20 °C
4.1: 72 percent / urea-hydrogen peroxide; phthalic anhydride / acetonitrile / 1 h / 0 °C
With
tetrachloromethane; lithium aluminium tetrahydride; phthalic anhydride; urea-hydrogen peroxide; sodium hydride; triphenylphosphine;
In
tetrahydrofuran; acetonitrile;
1.1: Reduction / 2.1: Chlorination / 3.1: Metallation / 3.2: coupling; Julia reaction / 4.1: Oxidation;
DOI:10.1021/jo990987r