(2-Butyl-5-chloro-3-{5-[2-(1-trityl-1H-tetrazol-5-yl)-phenyl]-benzofuran-2-ylmethyl}-3H-imidazol-4-yl)-methanol

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Chemical Name:(2-Butyl-5-chloro-3-{5-[2-(1-trityl-1H-tetrazol-5-yl)-phenyl]-benzofuran-2-ylmethyl}-3H-imidazol-4-yl)-methanol
CAS No.:188714-87-6
Molecular Formula:C₄₃H₃₇ClN₆O₂
Molecular Weight:705.259
Hs Code.:

Synonyms:(2-Butyl-5-chloro-3-{5-[2-(1-trityl-1H-tetrazol-5-yl)-phenyl]-benzofuran-2-ylmethyl}-3H-imidazol-4-yl)-methanol

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Chemical Property of (2-Butyl-5-chloro-3-{5-[2-(1-trityl-1H-tetrazol-5-yl)-phenyl]-benzofuran-2-ylmethyl}-3H-imidazol-4-yl)-methanol

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Technology Process of (2-Butyl-5-chloro-3-{5-[2-(1-trityl-1H-tetrazol-5-yl)-phenyl]-benzofuran-2-ylmethyl}-3H-imidazol-4-yl)-methanol

There total 8 articles about (2-Butyl-5-chloro-3-{5-[2-(1-trityl-1H-tetrazol-5-yl)-phenyl]-benzofuran-2-ylmethyl}-3H-imidazol-4-yl)-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 188714-86-5
2-Butyl-5-chloro-3-{5-[2-(1-trityl-1H-tetrazol-5-yl)-phenyl]-benzofuran-2-ylmethyl}-3H-imidazole-4-carbaldehyde

: 188714-87-6
(2-Butyl-5-chloro-3-{5-[2-(1-trityl-1H-tetrazol-5-yl)-phenyl]-benzofuran-2-ylmethyl}-3H-imidazol-4-yl)-methanol

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; for 1h; Ambient temperature;
DOI:10.1016/S0968-0896(96)00244-1

Reference yield:

: 84102-69-2
5-bromo-benzofuran-2-carboxylic acid ethyl ester

: 188714-87-6
(2-Butyl-5-chloro-3-{5-[2-(1-trityl-1H-tetrazol-5-yl)-phenyl]-benzofuran-2-ylmethyl}-3H-imidazol-4-yl)-methanol

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / Pd(OAc)2, PPh₃, aq. K₂CO₃ / tetrahydrofuran; 1,2-dimethoxy-ethane / 5 h / Heating

2: 76 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / Heating

3: CBr₄, PPh₃ / CH₂Cl₂ / 0.75 h / 0 °C

4: 73 percent / K₂CO₃ / dimethylformamide / 3 h / Heating

5: 75 percent / NaBH₄ / tetrahydrofuran / 1 h / Ambient temperature

With palladium diacetate; sodium tetrahydroborate; lithium aluminium tetrahydride; carbon tetrabromide; potassium carbonate; triphenylphosphine; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(96)00244-1

Reference yield:

: 90-02-8
salicylaldehyde

: 188714-87-6
(2-Butyl-5-chloro-3-{5-[2-(1-trityl-1H-tetrazol-5-yl)-phenyl]-benzofuran-2-ylmethyl}-3H-imidazol-4-yl)-methanol

Guidance literature:: Multi-step reaction with 8 steps

1: 79.3 percent / Br₂ / CS₂ / 50 °C

2: 1.) NaH / 1.) DMF, 30 min, 2.) DMF, 2 h

3: 1.) NaOEt, 2.) H₂SO₄ / 1.) EtOH, reflux, 3 h, 2.) EtOH, reflux, 1 h

4: 93 percent / Pd(OAc)2, PPh₃, aq. K₂CO₃ / tetrahydrofuran; 1,2-dimethoxy-ethane / 5 h / Heating

5: 76 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / Heating

6: CBr₄, PPh₃ / CH₂Cl₂ / 0.75 h / 0 °C

7: 73 percent / K₂CO₃ / dimethylformamide / 3 h / Heating

8: 75 percent / NaBH₄ / tetrahydrofuran / 1 h / Ambient temperature

With palladium diacetate; sodium tetrahydroborate; lithium aluminium tetrahydride; carbon tetrabromide; sulfuric acid; bromine; sodium ethanolate; sodium hydride; potassium carbonate; triphenylphosphine; In tetrahydrofuran; carbon disulfide; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(96)00244-1