(S)-2-{3-[(1S,2S)-[(S)-1-{[(9H-Fluoren-9-yl)methoxy]carbonyl}pyrrolidine-2-carboxamido]-1,2-diphenylethyl]thioureido}-2-phenylacetic acid

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Chemical Name:(S)-2-{3-[(1S,2S)-[(S)-1-{[(9H-Fluoren-9-yl)methoxy]carbonyl}pyrrolidine-2-carboxamido]-1,2-diphenylethyl]thioureido}-2-phenylacetic acid
CAS No.:1390673-03-6
Molecular Formula:C₄₃H₄₀N₄O₅S
Molecular Weight:724.88
Hs Code.:

Synonyms:(S)-2-{3-[(1S,2S)-[(S)-1-{[(9H-Fluoren-9-yl)methoxy]carbonyl}pyrrolidine-2-carboxamido]-1,2-diphenylethyl]thioureido}-2-phenylacetic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-{3-[(1S,2S)-[(S)-1-{[(9H-Fluoren-9-yl)methoxy]carbonyl}pyrrolidine-2-carboxamido]-1,2-diphenylethyl]thioureido}-2-phenylacetic acid

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Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-2-{3-[(1S,2S)-[(S)-1-{[(9H-Fluoren-9-yl)methoxy]carbonyl}pyrrolidine-2-carboxamido]-1,2-diphenylethyl]thioureido}-2-phenylacetic acid

There total 5 articles about (S)-2-{3-[(1S,2S)-[(S)-1-{[(9H-Fluoren-9-yl)methoxy]carbonyl}pyrrolidine-2-carboxamido]-1,2-diphenylethyl]thioureido}-2-phenylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1390672-74-8
(S)-(9H-fluoren-9-yl)methyl 2-[(1S,2S)-2-{3-[(S)-2-tert-butoxy-2-oxo-1-phenylethyl]thioureido}-1,2-diphenylethylcarbamoyl]pyrrolidine-1-carboxylate

: 1390673-03-6
(S)-2-{3-[(1S,2S)-[(S)-1-{[(9H-Fluoren-9-yl)methoxy]carbonyl}pyrrolidine-2-carboxamido]-1,2-diphenylethyl]thioureido}-2-phenylacetic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1039/c2ob25693b

Reference yield:

: 1390672-72-6
C₁₃H₁₅NO₂S

: 1390673-03-6
(S)-2-{3-[(1S,2S)-[(S)-1-{[(9H-Fluoren-9-yl)methoxy]carbonyl}pyrrolidine-2-carboxamido]-1,2-diphenylethyl]thioureido}-2-phenylacetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 18 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 24 h / 20 °C

With trifluoroacetic acid; In dichloromethane;
DOI:10.1039/c2ob25693b

Reference yield:

: 1390672-71-5
(S)-(9H-fluoren-9-yl)methyl 2-[(1S,2S)-2-amino-1,2-diphenylethylcarbamoyl]pyrrolidine-1-carboxylate

: 1390673-03-6
(S)-2-{3-[(1S,2S)-[(S)-1-{[(9H-Fluoren-9-yl)methoxy]carbonyl}pyrrolidine-2-carboxamido]-1,2-diphenylethyl]thioureido}-2-phenylacetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 18 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 24 h / 20 °C

With trifluoroacetic acid; In dichloromethane;
DOI:10.1039/c2ob25693b