methyl (S)-2-acetamido-3-(1-tosyl-1H-pyrrolo[2,3-f]quinolin-3-yl)propanoate

Base Information

Chemical Name:methyl (S)-2-acetamido-3-(1-tosyl-1H-pyrrolo[2,3-f]quinolin-3-yl)propanoate
CAS No.:1533429-98-9
Molecular Formula:C₂₄H₂₃N₃O₅S
Molecular Weight:465.53
Hs Code.:

Synonyms:methyl (S)-2-acetamido-3-(1-tosyl-1H-pyrrolo[2,3-f]quinolin-3-yl)propanoate

Suppliers and Price of methyl (S)-2-acetamido-3-(1-tosyl-1H-pyrrolo[2,3-f]quinolin-3-yl)propanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (S)-2-acetamido-3-(1-tosyl-1H-pyrrolo[2,3-f]quinolin-3-yl)propanoate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of methyl (S)-2-acetamido-3-(1-tosyl-1H-pyrrolo[2,3-f]quinolin-3-yl)propanoate

There total 7 articles about methyl (S)-2-acetamido-3-(1-tosyl-1H-pyrrolo[2,3-f]quinolin-3-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1533429-88-7
methyl (S)-2-amino-3-(1-tosyl-1H-pyrrolo[2,3-f]quinolin-3-yl)propanoate

: 108-24-7
acetic anhydride

: 1533429-98-9
methyl (S)-2-acetamido-3-(1-tosyl-1H-pyrrolo[2,3-f]quinolin-3-yl)propanoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/ol403429e

Reference yield:

: 1533429-84-3
1-tosyl-1H-pyrrolo[2,3-f]quinoline-3-carbaldehyde

: 1533429-98-9
methyl (S)-2-acetamido-3-(1-tosyl-1H-pyrrolo[2,3-f]quinolin-3-yl)propanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate / ethanol / 2 h / 20 °C

2.1: triethylamine; thionyl chloride / dichloromethane / -10 - 20 °C / Inert atmosphere

3.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

3.2: -78 - 20 °C / Inert atmosphere

4.1: hydrogenchloride / tetrahydrofuran; water / 2 h / 0 - 20 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

With hydrogenchloride; sodium tetrahydroborate; n-butyllithium; thionyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1021/ol403429e

Reference yield:

: 1533429-87-6
3-(((2S,5R)-5-isopropyl-3,6-dimethoxy-2,5-dihydropyrazin-2-yl)methyl)-1-tosyl-1H-pyrrolo[2,3-f] quinoline

: 1533429-98-9
methyl (S)-2-acetamido-3-(1-tosyl-1H-pyrrolo[2,3-f]quinolin-3-yl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / tetrahydrofuran; water / 2 h / 0 - 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/ol403429e