2-[[Hexahydro-4-(phenylmethyl)-1,4-oxazepin-2-yl]methyl]-1H-isoindole-1,3(2H)-dione

Base Information

Chemical Name:2-[[Hexahydro-4-(phenylmethyl)-1,4-oxazepin-2-yl]methyl]-1H-isoindole-1,3(2H)-dione
CAS No.:129482-46-8
Molecular Formula:C₂₁H₂₂N₂O₃
Molecular Weight:350.417
Hs Code.:
DSSTox Substance ID:DTXSID401130406

Synonyms:DTXSID401130406;2-[[Hexahydro-4-(phenylmethyl)-1,4-oxazepin-2-yl]methyl]-1H-isoindole-1,3(2H)-dione;129482-46-8

Suppliers and Price of 2-[[Hexahydro-4-(phenylmethyl)-1,4-oxazepin-2-yl]methyl]-1H-isoindole-1,3(2H)-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-[[Hexahydro-4-(phenylmethyl)-1,4-oxazepin-2-yl]methyl]-1H-isoindole-1,3(2H)-dione

Chemical Property:

XLogP3:2.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:350.16304257
Heavy Atom Count:26
Complexity:493

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CN(CC(OC1)CN2C(=O)C3=CC=CC=C3C2=O)CC4=CC=CC=C4

Technology Process of 2-[[Hexahydro-4-(phenylmethyl)-1,4-oxazepin-2-yl]methyl]-1H-isoindole-1,3(2H)-dione

There total 3 articles about 2-[[Hexahydro-4-(phenylmethyl)-1,4-oxazepin-2-yl]methyl]-1H-isoindole-1,3(2H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.2%

: 1074-82-4
potassium phtalimide

: 129482-45-7
4-benzyl-2-chloromethyl-[1,4]oxazepane

: 129482-46-8
4-benzyl-2-(phthalimidomethyl)hexahydro-1,4-oxazepine

Guidance literature:: In N,N-dimethyl-formamide; for 3h; Heating;
DOI:10.1021/jm00062a007

Reference yield:

: 309747-68-0
3-[Benzyl-(3-chloro-2-hydroxy-propyl)-amino]-propan-1-ol

: 129482-46-8
4-benzyl-2-(phthalimidomethyl)hexahydro-1,4-oxazepine

Guidance literature:: Multi-step reaction with 2 steps

1: H₂SO₄ / 0.5 h / 150 °C

2: 77.2 percent / dimethylformamide / 3 h / Heating

With sulfuric acid; In N,N-dimethyl-formamide;
DOI:10.1021/jm00062a007

Reference yield:

: 4720-29-0
3-(benzylamino)propan-1-ol

: 129482-46-8
4-benzyl-2-(phthalimidomethyl)hexahydro-1,4-oxazepine

Guidance literature:: Multi-step reaction with 3 steps

1: 2.5 h / 40 °C

2: H₂SO₄ / 0.5 h / 150 °C

3: 77.2 percent / dimethylformamide / 3 h / Heating

With sulfuric acid; In N,N-dimethyl-formamide;
DOI:10.1021/jm00062a007