methyl (2Z)-2-{[(benzyloxy)carbonyl]amino}-3-(5-methyl-2-furyl)acrylate

Base Information

• Chemical Name: methyl (2Z)-2-{[(benzyloxy)carbonyl]amino}-3-(5-methyl-2-furyl)acrylate
• CAS No.: 226880-80-4
• Molecular Formula: C₁₇H₁₇NO₅
• Molecular Weight: 315.326
• Mol file: 226880-80-4.mol

Synonyms:methyl (2Z)-2-{[(benzyloxy)carbonyl]amino}-3-(5-methyl-2-furyl)acrylate

Chemical Property of methyl (2Z)-2-{[(benzyloxy)carbonyl]amino}-3-(5-methyl-2-furyl)acrylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (2Z)-2-{[(benzyloxy)carbonyl]amino}-3-(5-methyl-2-furyl)acrylate

There total 1 articles about methyl (2Z)-2-{[(benzyloxy)carbonyl]amino}-3-(5-methyl-2-furyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

5-Methylfurfural (620-02-0) + N-(benzyloxycarbonyl)phosphonoglycine trimethyl ester (100945-15-1,88568-95-0) → methyl (2Z)-2-{[(benzyloxy)carbonyl]amino}-3-(5-methyl-2-furyl)acrylate (226880-80-4)

Guidance literature:

With potassium tert-butylate; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1002/chem.200600192

Reference yield: 98.0%

methyl (2Z)-2-{[(benzyloxy)carbonyl]amino}-3-(5-methyl-2-furyl)acrylate (226880-80-4) → methyl (2R)-(-)-2-benzyloxycarbonylamino-3-(5-methylfuran-2-yl)propanoate (226880-87-1)

Guidance literature:

With hydrogen; di(norbornadiene)rhodium(I) tetrafluoroborate; In methanol; toluene; at 20 ℃; for 16.5h; under 3750.38 Torr;

DOI:10.1002/chem.200600192

Reference yield: 92.0%

methyl (2Z)-2-{[(benzyloxy)carbonyl]amino}-3-(5-methyl-2-furyl)acrylate (226880-80-4) → methyl 2-benzyloxycarbonylamino-3-(5-methylfuran-2-yl)propanoate (904682-43-5)

Guidance literature:

With hydrogen; RhCl(PPh₃)3; In methanol; toluene; at 20 ℃; for 24h; under 3750.38 Torr;

DOI:10.1002/chem.200600192

upstream raw materials:

5-Methylfurfural

N-(benzyloxycarbonyl)phosphonoglycine trimethyl ester

Downstream raw materials:

methyl (2R)-(-)-2-benzyloxycarbonylamino-3-(5-methylfuran-2-yl)propanoate

methyl 2-benzyloxycarbonylamino-3-(5-methylfuran-2-yl)propanoate

methyl (2R)-(-)-2-{[(4-bromophenyl)sulfonyl]amino}-3-(5-methyl-2-furyl)propanoate

methyl 2-{[(4-bromophenyl)sulfonyl]amino}-3-(5-methyl-2-furyl)propanoate