{2-cyclopropyl-4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-quinazolin-6-yl}-methyl-(2-morpholin-4-yl-ethyl)-amine

Base Information

Chemical Name:{2-cyclopropyl-4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-quinazolin-6-yl}-methyl-(2-morpholin-4-yl-ethyl)-amine
CAS No.:1616294-96-2
Molecular Formula:C₂₉H₃₆N₆O₃
Molecular Weight:516.643
Hs Code.:

Synonyms:{2-cyclopropyl-4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-quinazolin-6-yl}-methyl-(2-morpholin-4-yl-ethyl)-amine

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Chemical Property of {2-cyclopropyl-4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-quinazolin-6-yl}-methyl-(2-morpholin-4-yl-ethyl)-amine

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Technology Process of {2-cyclopropyl-4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-quinazolin-6-yl}-methyl-(2-morpholin-4-yl-ethyl)-amine

There total 6 articles about {2-cyclopropyl-4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-quinazolin-6-yl}-methyl-(2-morpholin-4-yl-ethyl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: C₂₃H₂₇N₅O*ClH

: 50618-82-1
4-morpholineacetic acid chloride

: 1616294-96-2
{2-cyclopropyl-4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-quinazolin-6-yl}-methyl-(2-morpholin-4-yl-ethyl)-amine

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 2h; Cooling with ice;

Reference yield:

: 1616296-01-5
C₂₇H₃₃N₅O₃

: 1616294-96-2
{2-cyclopropyl-4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-quinazolin-6-yl}-methyl-(2-morpholin-4-yl-ethyl)-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 1.5 h / 0 °C

1.2: 20 °C

2.1: hydrogenchloride / ethyl acetate / 2 h / 20 °C

3.1: triethylamine / dichloromethane / 2 h / 20 °C / Cooling with ice

With hydrogenchloride; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane; ethyl acetate; mineral oil;

Reference yield:

: 1616295-99-8
C₂₂H₂₃N₅O₃

: 1616294-96-2
{2-cyclopropyl-4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-quinazolin-6-yl}-methyl-(2-morpholin-4-yl-ethyl)-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: iron; ammonium chloride / ethanol; water / 3 h / Reflux

2.1: dmap; triethylamine / dichloromethane / 5 h / 30 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 1.5 h / 0 °C

3.2: 20 °C

4.1: hydrogenchloride / ethyl acetate / 2 h / 20 °C

5.1: triethylamine / dichloromethane / 2 h / 20 °C / Cooling with ice

With hydrogenchloride; dmap; iron; sodium hydride; ammonium chloride; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; mineral oil;