N-(3-{4-[4-(6-hydroxymethyl-1-oxypyridin-3-yloxy)-3-methylphenylamino]quinazolin-6-yl}allyl)-2-methoxyacetamide

Base Information

Chemical Name:N-(3-{4-[4-(6-hydroxymethyl-1-oxypyridin-3-yloxy)-3-methylphenylamino]quinazolin-6-yl}allyl)-2-methoxyacetamide
CAS No.:916496-91-8
Molecular Formula:C₂₇H₂₇N₅O₅
Molecular Weight:501.542
Hs Code.:

Synonyms:N-(3-{4-[4-(6-hydroxymethyl-1-oxypyridin-3-yloxy)-3-methylphenylamino]quinazolin-6-yl}allyl)-2-methoxyacetamide

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Chemical Property of N-(3-{4-[4-(6-hydroxymethyl-1-oxypyridin-3-yloxy)-3-methylphenylamino]quinazolin-6-yl}allyl)-2-methoxyacetamide

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Technology Process of N-(3-{4-[4-(6-hydroxymethyl-1-oxypyridin-3-yloxy)-3-methylphenylamino]quinazolin-6-yl}allyl)-2-methoxyacetamide

There total 5 articles about N-(3-{4-[4-(6-hydroxymethyl-1-oxypyridin-3-yloxy)-3-methylphenylamino]quinazolin-6-yl}allyl)-2-methoxyacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98556-31-1
4-chloro-6-iodoquinazoline

: 916496-93-0
[5-(4-amino-2-methylphenoxy)-1-oxidopyridin-2-yl]methanol

: 916496-91-8
N-(3-{4-[4-(6-hydroxymethyl-1-oxypyridin-3-yloxy)-3-methylphenylamino]quinazolin-6-yl}allyl)-2-methoxyacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1,2-dichloro-ethane; tert-butyl alcohol / 0.5 h / 90 °C

2: triphenylphosphine / palladium diacetate / tetrahydrofuran; water / 18.5 h / 65 - 68 °C / Heating / reflux

With triphenylphosphine; palladium diacetate; In tetrahydrofuran; water; 1,2-dichloro-ethane; tert-butyl alcohol;

Reference yield:

: 916496-94-1
(5-{4-[(6-iodoquinazolin-4-yl)amino]-2-methylphenoxy}-1-oxidopyridin-2-yl)methanol

: 486393-59-3
N-allyl-2-methoxyacetamide

: 916496-91-8
N-(3-{4-[4-(6-hydroxymethyl-1-oxypyridin-3-yloxy)-3-methylphenylamino]quinazolin-6-yl}allyl)-2-methoxyacetamide

Guidance literature:: With triphenylphosphine; palladium diacetate; In tetrahydrofuran; water; at 65 - 68 ℃; for 18.5h; Heating / reflux;

Reference yield:

: 916496-92-9
[5-(2-methyl-4-nitrophenoxy)-1-oxidopyridin-2-yl]methanol

: 916496-91-8
N-(3-{4-[4-(6-hydroxymethyl-1-oxypyridin-3-yloxy)-3-methylphenylamino]quinazolin-6-yl}allyl)-2-methoxyacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / platinum(IV) oxide / ethyl acetate / 0.17 h / 2068.65 Torr

2: 1,2-dichloro-ethane; tert-butyl alcohol / 0.5 h / 90 °C

3: triphenylphosphine / palladium diacetate / tetrahydrofuran; water / 18.5 h / 65 - 68 °C / Heating / reflux

With hydrogen; triphenylphosphine; platinum(IV) oxide; palladium diacetate; In tetrahydrofuran; water; ethyl acetate; 1,2-dichloro-ethane; tert-butyl alcohol;