2-(tert-Butyl-dimethyl-silanyloxy)-4-[(2S,4aR,6R,7R,8R,8aR)-7,8-dihydroxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-6-ylsulfanyl]-butyronitrile

Base Information

Chemical Name:2-(tert-Butyl-dimethyl-silanyloxy)-4-[(2S,4aR,6R,7R,8R,8aR)-7,8-dihydroxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-6-ylsulfanyl]-butyronitrile
CAS No.:874634-84-1
Molecular Formula:C₂₄H₃₇NO₇SSi
Molecular Weight:511.712
Hs Code.:

2-(tert-Butyl-dimethyl-silanyloxy)-4-[(2S,4aR,6R,7R,8R,8aR)-7,8-dihydroxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-6-ylsulfanyl]-butyronitrile

Synonyms:2-(tert-Butyl-dimethyl-silanyloxy)-4-[(2S,4aR,6R,7R,8R,8aR)-7,8-dihydroxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-6-ylsulfanyl]-butyronitrile

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Chemical Property of 2-(tert-Butyl-dimethyl-silanyloxy)-4-[(2S,4aR,6R,7R,8R,8aR)-7,8-dihydroxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-6-ylsulfanyl]-butyronitrile

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Technology Process of 2-(tert-Butyl-dimethyl-silanyloxy)-4-[(2S,4aR,6R,7R,8R,8aR)-7,8-dihydroxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-6-ylsulfanyl]-butyronitrile

There total 6 articles about 2-(tert-Butyl-dimethyl-silanyloxy)-4-[(2S,4aR,6R,7R,8R,8aR)-7,8-dihydroxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-6-ylsulfanyl]-butyronitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 572-10-1,4451-35-8,4451-36-9,14227-52-2,14227-87-3,14227-88-4,14257-40-0,17081-03-7,19186-60-8,57237-01-1,65982-17-4,65982-18-5,65982-19-6,66966-08-3,144299-57-0
2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl chloride

: 874634-84-1
2-(tert-Butyl-dimethyl-silanyloxy)-4-[(2S,4aR,6R,7R,8R,8aR)-7,8-dihydroxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-6-ylsulfanyl]-butyronitrile

Guidance literature:: Multi-step reaction with 6 steps

1: 50 °C

2: 89 percent / NaOMe / methanol / -25 °C

3: dimethylformamide

4: acetonitrile

5: NaOMe / methanol

6: CSA / dimethylformamide

With camphor-10-sulfonic acid; sodium methylate; In methanol; N,N-dimethyl-formamide; acetonitrile; 3: Michael addition;
DOI:10.1016/j.bmcl.2005.08.019

Reference yield:

: Acetic acid (2R,3S,4S,5R,6R)-3,5-diacetoxy-2-acetoxymethyl-6-(3-oxo-propylsulfanyl)-tetrahydro-pyran-4-yl ester

: 874634-84-1
2-(tert-Butyl-dimethyl-silanyloxy)-4-[(2S,4aR,6R,7R,8R,8aR)-7,8-dihydroxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-6-ylsulfanyl]-butyronitrile

Guidance literature:: Multi-step reaction with 3 steps

1: acetonitrile

2: NaOMe / methanol

3: CSA / dimethylformamide

With camphor-10-sulfonic acid; sodium methylate; In methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2005.08.019

Reference yield:

: 870192-82-8
Acetic acid (2R,3S,4S,5R,6R)-3,5-diacetoxy-2-acetoxymethyl-6-[3-(tert-butyl-dimethyl-silanyloxy)-3-cyano-propylsulfanyl]-tetrahydro-pyran-4-yl ester

: 874634-84-1
2-(tert-Butyl-dimethyl-silanyloxy)-4-[(2S,4aR,6R,7R,8R,8aR)-7,8-dihydroxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-6-ylsulfanyl]-butyronitrile

Guidance literature:: Multi-step reaction with 2 steps

1: NaOMe / methanol

2: CSA / dimethylformamide

With camphor-10-sulfonic acid; sodium methylate; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.08.019