9-methoxy-5-methyl-1-(4-methoxy-phenyl)-3,4-dihydro-6H-pyrido[4,3-b]carbazole

Base Information

• Chemical Name: 9-methoxy-5-methyl-1-(4-methoxy-phenyl)-3,4-dihydro-6H-pyrido[4,3-b]carbazole
• CAS No.: 889653-91-2
• Molecular Formula: C₂₄H₂₂N₂O₂
• Molecular Weight: 370.451
• Mol file: 889653-91-2.mol

Synonyms:9-methoxy-5-methyl-1-(4-methoxy-phenyl)-3,4-dihydro-6H-pyrido[4,3-b]carbazole

Chemical Property of 9-methoxy-5-methyl-1-(4-methoxy-phenyl)-3,4-dihydro-6H-pyrido[4,3-b]carbazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9-methoxy-5-methyl-1-(4-methoxy-phenyl)-3,4-dihydro-6H-pyrido[4,3-b]carbazole

There total 3 articles about 9-methoxy-5-methyl-1-(4-methoxy-phenyl)-3,4-dihydro-6H-pyrido[4,3-b]carbazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.8%

N-[2-(6-methoxy-1-methyl-9H-carbazol-2-yl)ethyl]-4-methoxy-benzamide (889653-89-8) → 9-methoxy-5-methyl-1-(4-methoxy-phenyl)-3,4-dihydro-6H-pyrido[4,3-b]carbazole (889653-91-2)

Guidance literature:

With trichlorophosphate; In toluene; for 12h; Heating;

DOI:10.1002/ardp.200500141

Reference yield:

4-methoxybenzoic acid (100-09-4) → 9-methoxy-5-methyl-1-(4-methoxy-phenyl)-3,4-dihydro-6H-pyrido[4,3-b]carbazole (889653-91-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Et₃N; ethyl chloroformate / tetrahydrofuran / 0.5 h / -10 °C

1.2: 86.4 percent / tetrahydrofuran / -10 - 20 °C

2.1: 89.8 percent / phosphorous oxychloride / toluene / 12 h / Heating

With chloroformic acid ethyl ester; triethylamine; trichlorophosphate; In tetrahydrofuran; toluene;

DOI:10.1002/ardp.200500141

Reference yield:

2-(6-methoxy-1-methyl-9H-carbazol-2-yl)ethylamine (95835-25-9) → 9-methoxy-5-methyl-1-(4-methoxy-phenyl)-3,4-dihydro-6H-pyrido[4,3-b]carbazole (889653-91-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Et₃N; ethyl chloroformate / tetrahydrofuran / 0.5 h / -10 °C

1.2: 86.4 percent / tetrahydrofuran / -10 - 20 °C

2.1: 89.8 percent / phosphorous oxychloride / toluene / 12 h / Heating

With chloroformic acid ethyl ester; triethylamine; trichlorophosphate; In tetrahydrofuran; toluene;

DOI:10.1002/ardp.200500141

upstream raw materials:

N-[2-(6-methoxy-1-methyl-9H-carbazol-2-yl)ethyl]-4-methoxy-benzamide

4-methoxybenzoic acid

2-(6-methoxy-1-methyl-9H-carbazol-2-yl)ethylamine

Downstream raw materials:

9-methoxy-5-methyl-1-(4-methoxy-phenyl)-6H-pyrido[4,3-b]carbazole

5,6-dimethyl-9-hydroxy-1-(4'-hydroxyphenyl)-6H-pyrido[4,3-b]-carbazole

4-(9-methoxy-5,6-dimethyl-6H-pyrido[4,3-b]carbazol-1-yl)-phenol

9-methoxy-1-(4-methoxy-phenyl)-5,6-dimethyl-6H-pyrido[4,3-b]carbazole