2-butoxyquinoline-4-carboxylic Acid

Base Information

• Chemical Name: 2-butoxyquinoline-4-carboxylic Acid
• CAS No.: 10222-61-4
• Molecular Formula: C₁₄H₁₅NO₃
• Molecular Weight: 245.278
• UNII: WW4AV6ZX47
• Mol file: 10222-61-4.mol

Synonyms:2-butoxyquinoline-4-carboxylic Acid;10222-61-4;Dibucaine Impurity D;4-Quinolinecarboxylic acid, 2-butoxy-;2-(n-butyloxy)-4-quinolinecarboxylic acid;WW4AV6ZX47;Cinchoninic acid, 2-butoxy-;2-Butoxyquinoline-4-carboxylicAcid;2-Butoxy-4-quinolinecarboxylic acid;butyloxycinchoninic acid;UNII-WW4AV6ZX47;SCHEMBL6250517;ZISCTCXYESUBGA-UHFFFAOYSA-N;BCP24400;MFCD11527607;2-n-Butoxy-4-quinolinecarboxylic acid;AKOS009411458;DS-9690;SB72026;Cinchocaine hydrochloride impurity D [EP];CS-0186594;I11553;CINCHOCAINE HYDROCHLORIDE IMPURITY D [EP IMPURITY]

Chemical Property of 2-butoxyquinoline-4-carboxylic Acid

Chemical Property:

• Melting Point: 111 °C
• Boiling Point: 392.9±22.0 °C(Predicted)
• PKA: 1.06±0.10(Predicted)
• Density: 1.209±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 3.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 245.10519334
• Heavy Atom Count: 18
• Complexity: 282

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Butoxyquinoline-4-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCOC1=NC2=CC=CC=C2C(=C1)C(=O)O

Technology Process of 2-butoxyquinoline-4-carboxylic Acid

There total 4 articles about 2-butoxyquinoline-4-carboxylic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-(n-butyloxy)-4-(n-butyloxycarbonyl)-quinoline (107779-36-2) → 2-(n-butyloxy)-4-quinolinecarboxylic acid (10222-61-4)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; water; for 0.5h; Ambient temperature;

DOI:10.1021/jm00104a016

Reference yield: 34.0%

1-iodo-butane (542-69-8) + 2-hydroxyquinoline-4-carboxylic acid (15733-89-8,84906-81-0) → 2-(n-butyloxy)-4-quinolinecarboxylic acid (10222-61-4)

Guidance literature:

In N-methyl-acetamide;

Reference yield:

2-chloroquinoline-4-carboxylic acid (5467-57-2) + sodium butanolate (2372-45-4) → 2-(n-butyloxy)-4-quinolinecarboxylic acid (10222-61-4)

Guidance literature:

With butan-1-ol;

DOI:10.1002/ardp.19312692406

upstream raw materials:

2-chloroquinoline-4-carboxylic acid

sodium butanolate

2-(n-butyloxy)-4-(n-butyloxycarbonyl)-quinoline

1-iodo-butane

Refernces

• 1、 -. "QUINOLINE DERIVATIVE HAVING SEROTONIN-3 RECEPTOR ANTAGONIZING ACTIVITY". . . Retrieved 2008/06/13.
• 2、 BUECHI,PERLIA. "Relations between the physical-chemical properties and the effect of local anesthetics. Part 5.". . p. 465 - 467. Retrieved 2007/10/04.