5'-(1,3-dimethyl-5-propionyl-1H-pyrrol-2-yl)-2'-methoxy-[1,1'-biphenyl]-4-sulfonamide

Base Information

Chemical Name:5'-(1,3-dimethyl-5-propionyl-1H-pyrrol-2-yl)-2'-methoxy-[1,1'-biphenyl]-4-sulfonamide
CAS No.:1417797-78-4
Molecular Formula:C₂₂H₂₄N₂O₄S
Molecular Weight:412.51
Hs Code.:

Synonyms:5'-(1,3-dimethyl-5-propionyl-1H-pyrrol-2-yl)-2'-methoxy-[1,1'-biphenyl]-4-sulfonamide

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Chemical Property of 5'-(1,3-dimethyl-5-propionyl-1H-pyrrol-2-yl)-2'-methoxy-[1,1'-biphenyl]-4-sulfonamide

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Technology Process of 5'-(1,3-dimethyl-5-propionyl-1H-pyrrol-2-yl)-2'-methoxy-[1,1'-biphenyl]-4-sulfonamide

There total 5 articles about 5'-(1,3-dimethyl-5-propionyl-1H-pyrrol-2-yl)-2'-methoxy-[1,1'-biphenyl]-4-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.12%

: 1417798-34-5
5-(4'-(N-((dimethylamino)methylene)sulfamoyl)-6-methoxy-[1,1'-biphenyl]-3-yl)-N-methoxy-N,1,4-trimethyl-1H-pyrrole-2-carboxamide

: 925-90-6
ethylmagnesium bromide

: 1417797-78-4
5'-(1,3-dimethyl-5-propionyl-1H-pyrrol-2-yl)-2'-methoxy-[1,1'-biphenyl]-4-sulfonamide

Guidance literature:: 5-(4'-(N-((dimethylamino)methylene)sulfamoyl)-6-methoxy-[1,1'-biphenyl]-3-yl)-N-methoxy-N,1,4-trimethyl-1H-pyrrole-2-carboxamide; ethylmagnesium bromide; In tetrahydrofuran; at 25 - 75 ℃; for 1h;

With ammonium chloride; In tetrahydrofuran; water; at 0 ℃;

Reference yield:

: 1417798-26-5
methyl 5-(3-bromo-4-methoxyphenyl)-1,4-dimethyl-1H-pyrrole-2-carboxylate

: 1417797-78-4
5'-(1,3-dimethyl-5-propionyl-1H-pyrrol-2-yl)-2'-methoxy-[1,1'-biphenyl]-4-sulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / toluene; ethanol / 0.25 h / 25 °C / Inert atmosphere

1.2: 1 h / 95 - 100 °C / Inert atmosphere; Sealed tube

2.1: sodium hydroxide; water / ethanol / 15 h / 0 - 25 °C

2.2: pH 6 - 7

3.1: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 15 h / 0 - 20 °C

4.1: N,N-dimethyl-formamide; ethyl acetate / 15 h / 20 °C / Inert atmosphere

5.1: tetrahydrofuran / 1 h / 25 - 75 °C

5.2: 0 °C

With water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; ethyl acetate; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1417798-28-7
methyl 5-(6-methoxy-4'-sulfamoyl-[1,1'-biphenyl]-3-yl)-1,4-dimethyl-1H-pyrrole-2-carboxylate

: 1417797-78-4
5'-(1,3-dimethyl-5-propionyl-1H-pyrrol-2-yl)-2'-methoxy-[1,1'-biphenyl]-4-sulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide; water / ethanol / 15 h / 0 - 25 °C

1.2: pH 6 - 7

2.1: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 15 h / 0 - 20 °C

3.1: N,N-dimethyl-formamide; ethyl acetate / 15 h / 20 °C / Inert atmosphere

4.1: tetrahydrofuran / 1 h / 25 - 75 °C

4.2: 0 °C

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; ethyl acetate; N,N-dimethyl-formamide;