Technology Process of 17β-tert-Butoxy-1,3-dimethoxy-7β-(phenylsulfonyl)-1,3,5(10)-oestratrien
There total 9 articles about 17β-tert-Butoxy-1,3-dimethoxy-7β-(phenylsulfonyl)-1,3,5(10)-oestratrien which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
ethanol; benzene;
for 3h;
Ambient temperature;
DOI:10.1002/jlac.198219820306
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 77 percent / tetramethylethylenediamine / acetic acid / 60 h / 35 °C
2: 70 percent / H2, 1N HCl / 10percent Pd/C / ethanol
3: 75 percent / conc. H2SO4, HC(OC2H5)3 / dioxane / 24 h / Ambient temperature
4: 32 percent / LDA / tetrahydrofuran / 12 h / -20 °C
5: 81 percent / (CF3CO)2O, CF3COOH / toluene / 0.5 h / Ambient temperature
6: 79 percent / H2 / Pd/C / benzene; ethanol / 3 h / Ambient temperature
With
hydrogenchloride; N,N,N,N,-tetramethylethylenediamine; sulfuric acid; hydrogen; orthoformic acid triethyl ester; trifluoroacetic acid; trifluoroacetic anhydride; lithium diisopropyl amide;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; ethanol; acetic acid; toluene; benzene;
DOI:10.1002/jlac.198219820306
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 70 percent / H2, 1N HCl / 10percent Pd/C / ethanol
2: 75 percent / conc. H2SO4, HC(OC2H5)3 / dioxane / 24 h / Ambient temperature
3: 32 percent / LDA / tetrahydrofuran / 12 h / -20 °C
4: 81 percent / (CF3CO)2O, CF3COOH / toluene / 0.5 h / Ambient temperature
5: 79 percent / H2 / Pd/C / benzene; ethanol / 3 h / Ambient temperature
With
hydrogenchloride; sulfuric acid; hydrogen; orthoformic acid triethyl ester; trifluoroacetic acid; trifluoroacetic anhydride; lithium diisopropyl amide;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; ethanol; toluene; benzene;
DOI:10.1002/jlac.198219820306
