4-((1R,3R)-3-(((5-chloro-2-methoxyphenyl)amino)methyl)-2,2-dimethylcyclopropyl)-benzenesulfonamide

Base Information

Chemical Name:4-((1R,3R)-3-(((5-chloro-2-methoxyphenyl)amino)methyl)-2,2-dimethylcyclopropyl)-benzenesulfonamide
CAS No.:1557240-80-8
Molecular Formula:C₁₉H₂₃ClN₂O₃S
Molecular Weight:394.922
Hs Code.:

Synonyms:4-((1R,3R)-3-(((5-chloro-2-methoxyphenyl)amino)methyl)-2,2-dimethylcyclopropyl)-benzenesulfonamide

Suppliers and Price of 4-((1R,3R)-3-(((5-chloro-2-methoxyphenyl)amino)methyl)-2,2-dimethylcyclopropyl)-benzenesulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 4-((1R,3R)-3-(((5-chloro-2-methoxyphenyl)amino)methyl)-2,2-dimethylcyclopropyl)-benzenesulfonamide

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-((1R,3R)-3-(((5-chloro-2-methoxyphenyl)amino)methyl)-2,2-dimethylcyclopropyl)-benzenesulfonamide

There total 9 articles about 4-((1R,3R)-3-(((5-chloro-2-methoxyphenyl)amino)methyl)-2,2-dimethylcyclopropyl)-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: (1R,3R)-N-(5-chloro-2-methoxyphenyl)-2,2-dimethyl-3-(4-sulfamoylphenyl)-cyclopropane-1-carboxamide

: 1557240-80-8
4-((1R,3R)-3-(((5-chloro-2-methoxyphenyl)amino)methyl)-2,2-dimethylcyclopropyl)-benzenesulfonamide

Guidance literature:: With borane-THF; In tetrahydrofuran; at 0 ℃; for 3.5h; Inert atmosphere; Reflux;
DOI:10.1021/acsmedchemlett.9b00001

Reference yield: 47.0%

: 1557240-80-8
4-((1R,3R)-3-(((5-chloro-2-methoxyphenyl)amino)methyl)-2,2-dimethylcyclopropyl)-benzenesulfonamide

Guidance literature:: With borane-THF; In tetrahydrofuran; at 0 ℃; for 4h; Inert atmosphere; Reflux;

Reference yield:

: 50672-13-4,99647-69-5
(±)-trans-2,2-dimethyl-3-phenylcyclopropanecarboxylic acid

: 1557240-80-8
4-((1R,3R)-3-(((5-chloro-2-methoxyphenyl)amino)methyl)-2,2-dimethylcyclopropyl)-benzenesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 1.75 h / 0 - 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; cyclohexane / 0.5 h / -78 °C / Inert atmosphere

2.2: -78 - 20 °C / Inert atmosphere

3.1: dihydrogen peroxide; lithium hydroxide / tetrahydrofuran; water / 2 h / 0 - 20 °C

4.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

4.2: 0 - 20 °C / Inert atmosphere

5.1: chlorosulfonic acid / 1 h / 0 - 20 °C / Inert atmosphere

6.1: ammonia / 1,4-dioxane / 0.5 h

7.1: borane-THF / tetrahydrofuran / 3.5 h / 0 °C / Inert atmosphere; Reflux

With chlorosulfonic acid; n-butyllithium; borane-THF; oxalyl dichloride; ammonia; dihydrogen peroxide; N,N-dimethyl-formamide; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; cyclohexane; water;
DOI:10.1021/acsmedchemlett.9b00001