1-(2,4-difluorophenyl)-6-fluoro-7-(4-amino-3-methoxyimino-4-methylpiperidin-1-yl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid

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Chemical Name:1-(2,4-difluorophenyl)-6-fluoro-7-(4-amino-3-methoxyimino-4-methylpiperidin-1-yl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid
CAS No.:1310458-59-3
Molecular Formula:C₂₂H₂₀F₃N₅O₄
Molecular Weight:475.427
Hs Code.:

Synonyms:1-(2,4-difluorophenyl)-6-fluoro-7-(4-amino-3-methoxyimino-4-methylpiperidin-1-yl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid

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Chemical Property of 1-(2,4-difluorophenyl)-6-fluoro-7-(4-amino-3-methoxyimino-4-methylpiperidin-1-yl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid

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Technology Process of 1-(2,4-difluorophenyl)-6-fluoro-7-(4-amino-3-methoxyimino-4-methylpiperidin-1-yl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid

There total 10 articles about 1-(2,4-difluorophenyl)-6-fluoro-7-(4-amino-3-methoxyimino-4-methylpiperidin-1-yl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1310521-59-5
C₇H₁₅N₃O

: 1310458-59-3
1-(2,4-difluorophenyl)-6-fluoro-7-(4-amino-3-methoxyimino-4-methylpiperidin-1-yl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid

Guidance literature:: With triethylamine; In acetonitrile; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.ejmech.2011.03.026

Reference yield:

: 52763-21-0
ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride

: 1310458-59-3
1-(2,4-difluorophenyl)-6-fluoro-7-(4-amino-3-methoxyimino-4-methylpiperidin-1-yl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: 5% Pd(II)/C(eggshell); hydrogen / ethanol / 4 h / 20 °C / 3750.38 Torr

2.1: sodium hydrogencarbonate / ethanol / 1 h / 20 °C

3.1: potassium carbonate / acetone / 1.5 h / 50 °C

4.1: triethylamine / ethanol / 2 h / 60 °C

5.1: sodium hydroxide / ethanol; water / 5 h / 20 °C

5.2: 0.5 h / 20 °C

6.1: triethylamine / dichloromethane / 2 h / -15 °C

7.1: ammonia / dichloromethane / 2 h / 0 °C

8.1: sodium hypobromide / acetonitrile / 10 h / 5 °C

9.1: hydrogenchloride / dichloromethane / 1 h / 20 °C

10.1: triethylamine / acetonitrile / 20 °C / Inert atmosphere

With hydrogenchloride; sodium hypobromide; 5% Pd(II)/C(eggshell); ammonia; hydrogen; sodium hydrogencarbonate; potassium carbonate; triethylamine; sodium hydroxide; In ethanol; dichloromethane; water; acetone; acetonitrile; 8.1: Hofmann degradation;
DOI:10.1016/j.ejmech.2011.03.026

Reference yield:

: 71233-25-5
ethyl 1-tert-butoxycarbonyl-3-oxopiperidine-4-carboxylate

: 1310458-59-3
1-(2,4-difluorophenyl)-6-fluoro-7-(4-amino-3-methoxyimino-4-methylpiperidin-1-yl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium carbonate / acetone / 1.5 h / 50 °C

2.1: triethylamine / ethanol / 2 h / 60 °C

3.1: sodium hydroxide / ethanol; water / 5 h / 20 °C

3.2: 0.5 h / 20 °C

4.1: triethylamine / dichloromethane / 2 h / -15 °C

5.1: ammonia / dichloromethane / 2 h / 0 °C

6.1: sodium hypobromide / acetonitrile / 10 h / 5 °C

7.1: hydrogenchloride / dichloromethane / 1 h / 20 °C

8.1: triethylamine / acetonitrile / 20 °C / Inert atmosphere

With hydrogenchloride; sodium hypobromide; ammonia; potassium carbonate; triethylamine; sodium hydroxide; In ethanol; dichloromethane; water; acetone; acetonitrile; 6.1: Hofmann degradation;
DOI:10.1016/j.ejmech.2011.03.026