2-[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)amino]-N-[5-(3,5-difluorobenzyl)-1H-indazol-3-yl]-4-(4-methylpiperazin-1-yl)-benzamide

Base Information

Chemical Name:2-[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)amino]-N-[5-(3,5-difluorobenzyl)-1H-indazol-3-yl]-4-(4-methylpiperazin-1-yl)-benzamide
CAS No.:1108746-57-1
Molecular Formula:C₃₄H₄₄F₂N₆O₂Si
Molecular Weight:634.845
Hs Code.:

Synonyms:2-[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)amino]-N-[5-(3,5-difluorobenzyl)-1H-indazol-3-yl]-4-(4-methylpiperazin-1-yl)-benzamide

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Chemical Property of 2-[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)amino]-N-[5-(3,5-difluorobenzyl)-1H-indazol-3-yl]-4-(4-methylpiperazin-1-yl)-benzamide

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Technology Process of 2-[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)amino]-N-[5-(3,5-difluorobenzyl)-1H-indazol-3-yl]-4-(4-methylpiperazin-1-yl)-benzamide

There total 6 articles about 2-[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)amino]-N-[5-(3,5-difluorobenzyl)-1H-indazol-3-yl]-4-(4-methylpiperazin-1-yl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1108745-30-7
5-(3,5-difluoro-benzyl)-1H-indazol-3-ylamine

: C₂₀H₃₄ClN₃O₂Si

: 1108746-57-1
2-[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)amino]-N-[5-(3,5-difluorobenzyl)-1H-indazol-3-yl]-4-(4-methylpiperazin-1-yl)-benzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at -20 ℃; for 4h;
DOI:10.1021/acs.jmedchem.6b00064

Reference yield:

: 214210-21-6
3-cyano-4-fluorophenylboronic acid

: 1108746-57-1
2-[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)amino]-N-[5-(3,5-difluorobenzyl)-1H-indazol-3-yl]-4-(4-methylpiperazin-1-yl)-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 1.5 - 8 h / 100 °C / Inert atmosphere

2: hydrazine hydrate / butan-1-ol / Reflux

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 4 h / -20 °C

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; toluene; butan-1-ol; 1: |Suzuki-Miyaura Coupling;
DOI:10.1021/acs.jmedchem.6b00064

Reference yield:

: C₂₀H₃₅N₃O₃Si

: 1108746-57-1
2-[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)amino]-N-[5-(3,5-difluorobenzyl)-1H-indazol-3-yl]-4-(4-methylpiperazin-1-yl)-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 4 h / -20 °C

With oxalyl dichloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/acs.jmedchem.6b00064