(6S,9R,15S,18R)-methyl 9,18-diallyl-15-benzyl-6-(4-hydroxybenzyl)-2,2-dimethyl-4,7,10,13,16-pentaoxo-3-oxa-5,8,11,14,17-pentaazanonadecan-19-oate

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Chemical Name:(6S,9R,15S,18R)-methyl 9,18-diallyl-15-benzyl-6-(4-hydroxybenzyl)-2,2-dimethyl-4,7,10,13,16-pentaoxo-3-oxa-5,8,11,14,17-pentaazanonadecan-19-oate
CAS No.:944918-33-6
Molecular Formula:C₃₆H₄₇N₅O₉
Molecular Weight:693.797
Hs Code.:

Synonyms:(6S,9R,15S,18R)-methyl 9,18-diallyl-15-benzyl-6-(4-hydroxybenzyl)-2,2-dimethyl-4,7,10,13,16-pentaoxo-3-oxa-5,8,11,14,17-pentaazanonadecan-19-oate

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Chemical Property of (6S,9R,15S,18R)-methyl 9,18-diallyl-15-benzyl-6-(4-hydroxybenzyl)-2,2-dimethyl-4,7,10,13,16-pentaoxo-3-oxa-5,8,11,14,17-pentaazanonadecan-19-oate

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Technology Process of (6S,9R,15S,18R)-methyl 9,18-diallyl-15-benzyl-6-(4-hydroxybenzyl)-2,2-dimethyl-4,7,10,13,16-pentaoxo-3-oxa-5,8,11,14,17-pentaazanonadecan-19-oate

There total 1 articles about (6S,9R,15S,18R)-methyl 9,18-diallyl-15-benzyl-6-(4-hydroxybenzyl)-2,2-dimethyl-4,7,10,13,16-pentaoxo-3-oxa-5,8,11,14,17-pentaazanonadecan-19-oate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₂H₃₀N₄O₅*C₂HF₃O₂

: 3978-80-1
Boc-Tyr-OH

: 944918-33-6
(6S,9R,15S,18R)-methyl 9,18-diallyl-15-benzyl-6-(4-hydroxybenzyl)-2,2-dimethyl-4,7,10,13,16-pentaoxo-3-oxa-5,8,11,14,17-pentaazanonadecan-19-oate

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1021/jm061048b

Reference yield: 72.0%

: 944918-33-6
(6S,9R,15S,18R)-methyl 9,18-diallyl-15-benzyl-6-(4-hydroxybenzyl)-2,2-dimethyl-4,7,10,13,16-pentaoxo-3-oxa-5,8,11,14,17-pentaazanonadecan-19-oate

: (5R,8R,Z)-methyl-5-benzyl-14-((S)-2-((tert-butoxycarbonyl)amino)-3-(4-hydroxyphenyl)propanamido)-3,6,1 5-trioxo-1,4,7-triazacyclopentadec-10-ene-8-carboxylate

Guidance literature:: With (Z)-2-Butene; C₃₇H₄₀Cl₂N₂ORuS₂; In tetrahydrofuran; at 22 - 35 ℃; Inert atmosphere; Glovebox; Sealed tube;

Reference yield: 72.0%

: 944918-33-6
(6S,9R,15S,18R)-methyl 9,18-diallyl-15-benzyl-6-(4-hydroxybenzyl)-2,2-dimethyl-4,7,10,13,16-pentaoxo-3-oxa-5,8,11,14,17-pentaazanonadecan-19-oate

: 944918-34-7
(5S,8R,13R,Z)-methyl 5-benzyl-13-((S)-2-((tert-butoxycarbonyl)amino)-3-(4-hydroxyphenyl)propanamido)-3,6,14-trioxo-1,4,7-triazacyclotetradec-10-ene-8-carboxylate

Guidance literature:: (6S,9R,15S,18R)-methyl 9,18-diallyl-15-benzyl-6-(4-hydroxybenzyl)-2,2-dimethyl-4,7,10,13,16-pentaoxo-3-oxa-5,8,11,14,17-pentaazanonadecan-19-oate; With (Z)-2-Butene; C₃₇H₄₀Cl₂N₂ORuS₂; In tetrahydrofuran; at 22 ℃; for 12h; Glovebox; Sealed tube; Inert atmosphere;

With C₃₇H₄₀Cl₂N₂ORuS₂; In tetrahydrofuran; at 35 ℃; for 48h; stereoselective reaction; Inert atmosphere;
DOI:10.1021/jacs.7b06552