Technology Process of (4S,E,E,E)-[4-2H1]-5-benzenesulfonyl-1-benzyloxy-3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraene
There total 5 articles about (4S,E,E,E)-[4-2H1]-5-benzenesulfonyl-1-benzyloxy-3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(E,E)-farnesyl phenylsulfone;
With
n-butyllithium;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane;
at -78 - -23 ℃;
for 1.16667h;
(R,E)-[1-2H1]-4-benzyloxy-2-methyl-2-buten-1-yl methanesulfonate;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane;
at -78 - -23 ℃;
for 3h;
DOI:10.1021/jo0502091
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 99 percent / Et3N / CH2Cl2 / 1 h / 0 °C
2.1: n-BuLi / hexamethylphosphoric acid triamide; tetrahydrofuran; hexane / 1.17 h / -78 - -23 °C
2.2: 50 percent / hexamethylphosphoric acid triamide; tetrahydrofuran; hexane / 3 h / -78 - -23 °C
With
n-butyllithium; triethylamine;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; dichloromethane;
DOI:10.1021/jo0502091
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 49 percent / (S)-Alpine borane / tetrahydrofuran / 16 h / 20 °C
2.1: 99 percent / Et3N / CH2Cl2 / 1 h / 0 °C
3.1: n-BuLi / hexamethylphosphoric acid triamide; tetrahydrofuran; hexane / 1.17 h / -78 - -23 °C
3.2: 50 percent / hexamethylphosphoric acid triamide; tetrahydrofuran; hexane / 3 h / -78 - -23 °C
With
n-butyllithium; S-alpine borane; triethylamine;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; dichloromethane;
DOI:10.1021/jo0502091
![(R,E)-[1-2H<sub>1</sub>]-4-benzyloxy-2-methyl-2-buten-1-yl methanesulfonate](/Databaselist/images/loading.webp)
