2-FLUORO-3-METHYLBENZYL BROMIDE

Base Information

• Chemical Name: 2-FLUORO-3-METHYLBENZYL BROMIDE
• CAS No.: 151412-12-3
• Molecular Formula: C8H8BrF
• Molecular Weight: 203.054
• Hs Code.: 2903999090
• Mol file: 151412-12-3.mol

Synonyms:1-(Bromomethyl)-2-fluoro-3-methylbenzene;2-Fluoro-3-methylbenzyl bromide;3-Methyl-2-fluorobenzyl bromide;

Chemical Property of 2-FLUORO-3-METHYLBENZYL BROMIDE

Chemical Property:

• Appearance/Colour: clear colorless to light yellow liquid
• Refractive Index: 1.5465-1.5495
• Boiling Point: 211.6 °C at 760 mmHg
• Flash Point: 84.5 °C
• PSA: 0.00000
• Density: 1.456 g/cm³
• LogP: 3.02900
• Storage Temp.: 2-8°C
• Sensitive.: Lachrymatory
• Water Solubility.: Insoluble in water.

Purity/Quality:

97% ^*data from raw suppliers

2-Fluoro-3-methylbenzylbromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C,Xn
• Statements: 34-51-22
• Safety Statements: 45-36/37/39-26

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Fluoro-3-methylbenzyl bromide, is used as a chemical and organic intermediate.

Technology Process of 2-FLUORO-3-METHYLBENZYL BROMIDE

There total 5 articles about 2-FLUORO-3-METHYLBENZYL BROMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2-fluoro-3-methylphenyl)methanol (307975-03-7) → 2-fluoro-3-methylbenzyl bromide (151412-12-3)

Guidance literature:

With carbon tetrabromide; triphenylphosphine;

DOI:10.1016/S0960-894X(00)00416-9

Reference yield:

2-fluoro-m-xylene (443-88-9) → 2-fluoro-3-methylbenzyl bromide (151412-12-3)

Guidance literature:

2-fluoro-m-xylene; With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; for 12h; Reflux;

With sodium sulfite; In water;

DOI:10.1002/ejoc.201601608

Reference yield:

2-fluoro-3-methyl benzaldehyde (886762-64-7) → 2-fluoro-3-methylbenzyl bromide (151412-12-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate; methanol / 0.17 h / 0 °C

2: phosphorus tribromide / diethyl ether / 3 h / 0 - 20 °C

With methanol; sodium tetrahydroborate; phosphorus tribromide; In diethyl ether;

DOI:10.1002/ejoc.201601608

upstream raw materials:

(2-fluoro-3-methylphenyl)methanol

2-Fluorotoluene

2-fluoro-3-methylbenzoic acid

2-fluoro-m-xylene

Downstream raw materials:

5-{4-[(4-Chlorobenzyl)amino]phenyl}-6-{[(2-fluoro-3-methylbenzyl)oxy]methyl}pyrimidine-2,4-diamine

N-benzyl-2-(2-fluoro-3-methyl-benzyl)-morpholin-3-one

2-Fluoro-3-methyl-benzenemethanethiol