(4-iodophenyl)propargyl aldehyde

Base Information

• Chemical Name: (4-iodophenyl)propargyl aldehyde
• CAS No.: 1242772-11-7
• Molecular Formula: C₉H₅IO
• Molecular Weight: 256.043
• Mol file: 1242772-11-7.mol

Synonyms:(4-iodophenyl)propargyl aldehyde

Chemical Property of (4-iodophenyl)propargyl aldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-iodophenyl)propargyl aldehyde

There total 3 articles about (4-iodophenyl)propargyl aldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1-(4-iodophenyl)-1-propyn-3-ol (116815-00-0) → (4-iodophenyl)propargyl aldehyde (1242772-11-7)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 25 ℃; for 2h;

DOI:10.1039/c3nj00683b

Reference yield:

para-diiodobenzene (624-38-4,1032416-46-8) → (4-iodophenyl)propargyl aldehyde (1242772-11-7)

Guidance literature:

Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; diisopropylamine; copper(l) iodide / toluene / 20 °C / Inert atmosphere

2: manganese(IV) oxide / chloroform / 5 h / Inert atmosphere; Reflux

With manganese(IV) oxide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diisopropylamine; In chloroform; toluene; 1: |Sonogashira Cross-Coupling;

DOI:10.1080/00397911.2012.729280

Reference yield:

C13H15IO2 → (4-iodophenyl)propargyl aldehyde (1242772-11-7)

Guidance literature:

With hydrogenchloride; water; In acetone; at 20 ℃;

DOI:10.1021/acs.orglett.9b01003

upstream raw materials:

1-(4-iodophenyl)-1-propyn-3-ol

para-diiodobenzene

Downstream raw materials:

C₂₃H₁₄INO₂S

C₁₅H₁₁IN₂

(E)-1-methylthio-1-phenylsulphonyl-(4-(4-iodo)phenyl)-1-butene-3-yne