{2-oxo-2-[(2R)-1-(1R)-(1-phenylethyl)-aziridin-2-yl]ethyl}-phosphonic acid dimethyl ester

Base Information

Chemical Name:{2-oxo-2-[(2R)-1-(1R)-(1-phenylethyl)-aziridin-2-yl]ethyl}-phosphonic acid dimethyl ester
CAS No.:936628-37-4
Molecular Formula:C₁₄H₂₀NO₄P
Molecular Weight:297.291
Hs Code.:

Synonyms:{2-oxo-2-[(2R)-1-(1R)-(1-phenylethyl)-aziridin-2-yl]ethyl}-phosphonic acid dimethyl ester

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Chemical Property of {2-oxo-2-[(2R)-1-(1R)-(1-phenylethyl)-aziridin-2-yl]ethyl}-phosphonic acid dimethyl ester

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Technology Process of {2-oxo-2-[(2R)-1-(1R)-(1-phenylethyl)-aziridin-2-yl]ethyl}-phosphonic acid dimethyl ester

There total 1 articles about {2-oxo-2-[(2R)-1-(1R)-(1-phenylethyl)-aziridin-2-yl]ethyl}-phosphonic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 68820-82-6
(2R)-1[(R)-α-methylbenzyl]-2-aziridinecarboxylate ethyl ester

: 756-79-6
dimethyl methane phosphonate

: 936628-37-4
{2-oxo-2-[(2R)-1-(1R)-(1-phenylethyl)-aziridin-2-yl]ethyl}-phosphonic acid dimethyl ester

Guidance literature:: dimethyl methane phosphonate; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.5h;

(2R)-1[(R)-α-methylbenzyl]-2-aziridinecarboxylate ethyl ester; In tetrahydrofuran; at -78 - 20 ℃;
DOI:10.1016/j.tet.2007.02.045

Reference yield: 75.0%

: 936628-37-4
{2-oxo-2-[(2R)-1-(1R)-(1-phenylethyl)-aziridin-2-yl]ethyl}-phosphonic acid dimethyl ester

: 75-07-0,9002-91-9
acetaldehyde

: 936628-38-5
(E)-1-{(2R)-1-[(1R)-1-phenylethyl]-aziridin-2-yl}-2-buten-1-one

Guidance literature:: With potassium carbonate; In acetonitrile; at 20 ℃; for 24h;
DOI:10.1016/j.tet.2007.02.045

Reference yield:

: 936628-37-4
{2-oxo-2-[(2R)-1-(1R)-(1-phenylethyl)-aziridin-2-yl]ethyl}-phosphonic acid dimethyl ester

: (2S,3R)-1-[(1R)-1-phenylethyl]-2-phenylsulfanylmethyl-1,2,3,6-tetrahydropyridin-3-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 75 percent / K₂CO₃ / acetonitrile / 24 h / 20 °C

2: 40 percent / L-Selectride(R) / tetrahydrofuran / -78 - 20 °C

3: 83 percent / CH₂Cl₂ / 20 °C

4: 73 percent / NaH; (n-Bu)4NI / tetrahydrofuran; various solvent(s) / Heating

5: 74 percent / (Cy₃P)2Cl₂Ru=CHPh / toluene / Heating

With tetra-(n-butyl)ammonium iodide; L-Selectride; sodium hydride; potassium carbonate; Grubbs catalyst first generation; In tetrahydrofuran; dichloromethane; toluene; acetonitrile; 1: Horner-Wadsworth-Emmons olefination / 5: olefin metathesis;
DOI:10.1016/j.tet.2007.02.045